Evidence map›Paper›PMID 31076507›Full record

ArticleThe Journal of biological chemistry2019

Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian

Chen Wang, Zhen-Zhen Yang, Fang-Hao Guo, Shuo Shi, Xiao-Shuai Han, An Zeng, Haifan Lin, Qing Jing

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chen WangFrom the Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Zhen-Zhen YangFrom the Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.ORCID 0000-0002-4804-2045
Fang-Hao Guothe CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and.
Shuo ShiFrom the Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Xiao-Shuai Hanthe CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and.
An Zengthe CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and.
Haifan LinFrom the Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China, haifan.lin@yale.edu.
Qing Jingthe CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and qjing@sibs.ac.cn.ORCID 0000-0001-9834-1214
Shanghai Institute of Nutrition and Health · CNShanghaiTech University · CNYale Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIWI proteins are key regulators of germline and somatic stem cells throughout different evolutionary lineages. However, how PIWI proteins themselves are regulated remains largely unknown. To identify candidate proteins that interact with PIWI proteins and regulate their stability, here we established a yeast two-hybrid (Y2H) assay in the planarian species

Indexed as

HomeostasisRegenerationAnimalsArgonaute ProteinsEvolution, MolecularGene Expression ProfilingGene Expression RegulationHEK293 CellsHelminth ProteinsHSP40 Heat-Shock ProteinsHumansPlanariansRNA, Small InterferingStem CellsTwo-Hybrid System TechniquesArgonaute ProteinsDNAJA1 protein, humanHelminth ProteinsHSP40 Heat-Shock ProteinsPIWIL1 protein, humanRNA, Small InterferingArgonautechaperoneDNAJA1heat shock protein 40 (Hsp40)heat shock protein (HSP)neoblastPIWI-interacting RNA (piRNA)PIWI proteinsplanarianregenerationstem cells

Identifiers

PMID31076507
PMCPMC6597837
OpenAlexW2944277656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.