Evidence map›Paper›PMID 31076498›Full record

ArticleMolecular cancer research : MCR2019

A Ca

Donna K Dang, Monish Ram Makena, José P Llongueras, Hari Prasad, Myungjun Ko, Manuj Bandral, Rajini Rao

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. CaCellular signalling · 2023
    Review
  9. Article
  10. Translational cancer research · 2023
    Article
  11. Article
  12. Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases.Reviews of physiology, biochemistry and pharmacology · 2023
    Article
  13. Expression and associated epigenetic mechanisms of the CaJournal of cell communication and signaling · 2022
    Article
  14. Article
  15. Review
  16. CaCancers · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Donna K DangDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Monish Ram MakenaDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-4068-7375
José P LlonguerasDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Hari PrasadDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-0486-1919
Myungjun KoDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Manuj BandralDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7029-3385
Rajini RaoDepartment of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. rrao@jhmi.edu.ORCID 0000-0002-1833-5971
Johns Hopkins University · US

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Training Program In Cellular and Molecular MedicineT32GM135457 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAJINI RAO · 2020 to 2026
$5.4M
Transport Mechanism and Renal Function of a Newly Recognized Na+/H+ ExchangerR01DK108304 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2015 to 2019
$2.3M
Role of PC1, Pc2 and HDAC6 in cyst formation in ADPKDK08DK103078 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI CEBOTARU, VALERIU · 2014 to 2018
$779k
NIDDK NIH HHS K08 DK103078NIDDK NIH HHS R01 DK108304NIGMS NIH HHS T32 GM008752NIGMS NIH HHS T32 GM135457
6 · The paper itself

Abstract

Progression of benign tumors to invasive, metastatic cancer is accompanied by the epithelial-to-mesenchymal transition (EMT), characterized by loss of the cell-adhesion protein E-cadherin. Although silencing mutations and transcriptional repression of the E-cadherin gene have been widely studied, not much is known about posttranslational regulation of E-cadherin in tumors. We show that E-cadherin is tightly coexpressed with the secretory pathway Ca

Indexed as

Epithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticAnimalsAntigens, CDApoptosisBreast NeoplasmsCadherinsCalcium-Transporting ATPasesCell Cycle ProteinsCell MovementCell ProliferationFemaleHippo Signaling PathwayHumansMice, Inbred NODMice, SCIDAntigens, CDATP2C2 protein, humanCadherinsCalcium-Transporting ATPasesCDH1 protein, humanCell Cycle ProteinsProtein Serine-Threonine KinasesTranscription FactorsYY1AP1 protein, human

Identifiers

PMID31076498
PMCPMC6679749
OpenAlexW2944707829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.