Evidence map›Paper›PMID 31076476›Full record

ArticleBMJ open2019

TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study.

Matthew J Ridd, Louisa Edwards, Miriam Santer, Joanne R Chalmers, Lisa Waddell, Deborah Marriage, Ingrid Muller, Kirsty Roberts, Kirsty Garfield, Joanna Coast and 9 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 5 countries.

Matthew J RiddPopulation Health, University of Bristol, Bristol, UK.ORCID 0000-0002-7954-8823
Louisa EdwardsFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0001-9371-2805
Miriam SanterPrimary Care and Population Sciences, University of Southampton, Southampton, UK.
Joanne R ChalmersCentre for Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
Lisa WaddellNottingham CityCare, Nottingham, UK.
Deborah MarriageBristol Royal Hospital for Children, Bristol, UK.
Ingrid MullerFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Kirsty RobertsPopulation Health, University of Bristol, Bristol, UK.
Kirsty GarfieldBristol Randomised Trials Collaboration, University of Bristol, Bristol, UK.
Joanna CoastHealth Economics at Bristol, University of Bristol, Bristol, UK.
Lucy SelmanBristol Randomised Trials Collaboration, University of Bristol, Bristol, UK.
Clare ClementBristol Randomised Trials Collaboration, University of Bristol, Bristol, UK.
Alison R G ShawPopulation Health, University of Bristol, Bristol, UK.
Elizabeth AngierPrimary Care and Population Sciences, University of Southampton, Southampton, UK.
Peter S BlairCentre for Academic Child Health, University of Bristol, Bristol, UK.
Nicholas L TurnerHealth Economics at Bristol, University of Bristol, Bristol, UK.
Jodi TaylorBristol Randomised Trials Collaboration, University of Bristol, Bristol, UK.
Joe KaiDivision of Primary Care, University of Nottingham, Nottingham, UK.
Robert J BoyleImperial College London, London, UK.
University of Bristol · GBAt Bristol · GBPrimary Health Care · QASimon Fraser University · CAUniversity of Nottingham · GBBristol Royal Hospital for Children · GBImperial College London · GBNottingham City Council · GB

Funding

Medical Research Council MR/K025643/1
6 · The paper itself

Abstract

backgroundEarly onset eczema is associated with food allergy, and allergic reactions to foods can cause acute exacerbations of eczema. Parents often pursue dietary restrictions as a way of managing eczema and seek allergy testing for their children to guide dietary management. However, it is unclear whether test-guided dietary management improves eczema symptoms, and whether the practice causes harm through reduced use of conventional eczema treatment or unnecessary dietary restrictions. The aim of the Trial of Eczema allergy Screening Tests Study is to determine the feasibility of conducting a trial comparing food allergy testing and dietary advice versus usual care, for the management of eczema in children. METHODS AND ANALYSIS: Design: A single centre, two-group, individually randomised, feasibility randomised controlled trial (RCT) with economic scoping and a nested qualitative study.

settingGeneral Practioner (GP) surgeries in the west of England.

participantschildren aged over 3 months and less than 5 years with mild to severe eczema.

interventionsallergy testing (structured allergy history and skin prick tests) or usual care. Sample size and outcome measures: we aim to recruit 80 participants and follow them up using 4-weekly questionnaires for 24 weeks. Nested qualitative study: We will conduct ~20 interviews with parents of participating children, 5-8 interviews with parents who decline or withdraw from the trial and ~10 interviews with participating GPs. Economic scoping: We will gather data on key costs and outcomes to assess the feasibility of carrying out a cost-effectiveness analysis in a future definitive trial. ETHICS AND DISSEMINATION: The study has been reviewed by the Health Research Authority and given a favourable opinion by the NHS REC (West Midlands - South Birmingham Research Ethics Committee, Reference Number 18/WM/0124). Findings will be submitted for presentation at conferences and written up for publication in peer-reviewed journals, which may include mixed-method triangulation and integration of the quantitative and qualitative findings.

trial registrationISRCTN15397185; Pre-results.

Indexed as

Dermatitis, AtopicFood HypersensitivityChild, PreschoolEnglandFeasibility StudiesFemaleHealth Care CostsHumansInfantMalePrimary Health CareQualitative ResearchRandomized Controlled Trials as TopicSkin Testsallergyclinical trialseczema

Identifiers

PMID31076476
PMCPMC6527983
OpenAlexW2944220679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.