Evidence map›Paper›PMID 31076442›Full record

ArticleBlood2019

The enhancer RNA

Shi Hao Tan, Wei Zhong Leong, Phuong Cao Thi Ngoc, Tze King Tan, Fatima Carla Bertulfo, Mei Chee Lim, Omer An, Zhenhua Li, Allen Eng Juh Yeoh, Melissa J Fullwood and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
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  11. Comprehensive profiling of enhancer RNA in stage II/III colorectal cancer defines two prognostic subtypes with implications for immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
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  20. Enhancer RNAs in transcriptional regulation: recent insights.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Shi Hao TanCancer Science Institute of Singapore, National University of Singapore, Singapore.ORCID 0000-0002-7483-3668
Wei Zhong LeongCancer Science Institute of Singapore, National University of Singapore, Singapore.
Phuong Cao Thi NgocCancer Science Institute of Singapore, National University of Singapore, Singapore.
Tze King TanCancer Science Institute of Singapore, National University of Singapore, Singapore.
Fatima Carla BertulfoCancer Science Institute of Singapore, National University of Singapore, Singapore.
Mei Chee LimCancer Science Institute of Singapore, National University of Singapore, Singapore.ORCID 0000-0002-8338-9554
Omer AnCancer Science Institute of Singapore, National University of Singapore, Singapore.
Zhenhua LiDepartment of Paediatrics, National University of Singapore, Singapore.
Allen Eng Juh YeohDepartment of Paediatrics, National University of Singapore, Singapore.ORCID 0000-0002-6454-976X
Melissa J FullwoodCancer Science Institute of Singapore, National University of Singapore, Singapore.
Daniel G TenenCancer Science Institute of Singapore, National University of Singapore, Singapore.
Takaomi SandaCancer Science Institute of Singapore, National University of Singapore, Singapore.ORCID 0000-0003-1621-4954
National University of Singapore · SGHarvard University · US

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
NCI NIH HHS R35 CA197697NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

The oncogenic transcription factor TAL1 regulates the transcriptional program in T-ALL. ARID5B is one of the critical downstream targets of TAL1, which further activates the oncogenic regulatory circuit in T-ALL cells. Here, we elucidated the molecular functions of the noncoding RNA, ARID5B-inducing enhancer associated long noncoding RNA (

Indexed as

Gene Expression Regulation, LeukemicTranscription, GeneticAnimalsBinding SitesCarcinogenesisCell Line, TumorCell ProliferationCell SurvivalChromatin Immunoprecipitation SequencingDisease Models, AnimalDisease ProgressionDNA-Binding ProteinsEnhancer Elements, GeneticGene Knockdown TechniquesGene TargetingHeterograftsARID5B protein, humanDNA-Binding ProteinsMultiprotein ComplexesRNA, Long NoncodingT-Cell Acute Lymphocytic Leukemia Protein 1Transcription Factors

Identifiers

PMID31076442
PMCPMC8212351
OpenAlexW2944714879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.