Evidence map›Paper›PMID 31076409›Full record

Trial reportBlood advances2019

Efficacy and predictors of response of lenalidomide and rituximab in patients with treatment-naive and relapsed CLL.

Paolo Strati, Koichi Takahashi, Christine B Peterson, Michael J Keating, Philip A Thompson, Naval G Daver, Nitin Jain, Jan A Burger, Zeev Estrov, Susan M O'Brien and 4 more

Open access · goldAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Paolo StratiDepartment of Leukemia.
Koichi TakahashiDepartment of Leukemia.
Christine B PetersonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-3316-0468
Michael J KeatingDepartment of Leukemia.
Philip A ThompsonDepartment of Leukemia.
Naval G DaverDepartment of Leukemia.ORCID 0000-0001-7103-373X
Nitin JainDepartment of Leukemia.
Jan A BurgerDepartment of Leukemia.ORCID 0000-0002-6177-7572
Zeev EstrovDepartment of Leukemia.ORCID 0000-0002-1623-3613
Susan M O'BrienDepartment of Leukemia.
Hagop M KantarjianDepartment of Leukemia.ORCID 0000-0002-1908-3307
William G WierdaDepartment of Leukemia.
P Andrew FutrealDepartment of Genomic Medicine, and.
Alessandra FerrajoliDepartment of Leukemia.
Center for Genomic Science · ITThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

This phase 2 study was conducted to prospectively evaluate how clinical and biological factors correlate with outcome in patients with treatment-naive (TN) and relapsed (R) chronic lymphocytic leukemia (CLL) treated with lenalidomide and rituximab. Oral lenalidomide 10 mg was administered daily starting on day 9 of cycle 1. IV rituximab 375 mg/m

Indexed as

AdultAgedDrug Administration ScheduleFemaleHumansImmunologic FactorsKaplan-Meier EstimateLenalidomideLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedMultivariate AnalysisNeutropeniaProgression-Free SurvivalReceptors, NotchRecurrenceImmunologic FactorsLenalidomideReceptors, NotchRituximab

Identifiers

PMID31076409
PMCPMC6517659
OpenAlexW2944648053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.