ArticleNeuron2019
Positional Strategies for Connection Specificity and Synaptic Organization in Spinal Sensory-Motor Circuits.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- C3 and CD47 mediate sensory-motor circuit refinement during spinal cord development.The Journal of experimental medicine · 2026Article
- Defining spinal motor neuron subtypes across development: from embryonic specification to postnatal maturation.Frontiers in cellular neuroscience · 2026Review
- Review
- Chromosome-Level Genome Assembly of the Loach Goby Rhyacichthys aspro Offers Insights Into Gobioidei Evolution.Molecular ecology resources · 2025Article
- Canonical Proprioceptors Are Largely Absent in the Intrinsic Laryngeal Muscles of the Rat Larynx.The Journal of comparative neurology · 2025Article
- Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.eLife · 2024Article
- Structure and Topography of Facial Branchiomotor Neuron Dendrites in Larval Zebrafish (Danio rerio).The Journal of comparative neurology · 2024Article
- Position-independent functional refinement within the vagus motor topographic map.Cell reports · 2024Article
- Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Article
- Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024Article
- Position-independent functional refinement within the vagus motor topographic map.bioRxiv : the preprint server for biology · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.bioRxiv : the preprint server for biology · 2024Article
- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.bioRxiv : the preprint server for biology · 2023Article
- Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.Developmental cell · 2023Article
- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.Frontiers in neural circuits · 2023Article
- Article
- Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.eLife · 2022Article
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Abstract
Proprioceptive sensory axons in the spinal cord form selective connections with motor neuron partners, but the strategies that confer such selectivity remain uncertain. We show that muscle-specific sensory axons project to motor neurons along topographically organized angular trajectories and that motor pools exhibit diverse dendritic arbors. On the basis of spatial constraints on axo-dendritic interactions, we propose positional strategies that can account for sensory-motor connectivity and synaptic organization. These strategies rely on two patterning principles. First, the degree of axo-dendritic overlap reduces the number of potential post-synaptic partners. Second, a close correlation between the small angle of axo-dendritic approach and the formation of synaptic clusters imposes specificity of connections when sensory axons intersect multiple motor pools with overlapping dendritic arbors. Our study identifies positional strategies with prominent roles in the organization of spinal sensory-motor circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.