ArticlePathophysiology : the official journal of the International Society for Pathophysiology
Pathophysiology of acute fibrinous and organizing pneumonia - Clinical and morphological spectra.
Article in Pathophysiology : the official journal of the International Society for Pathophysiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Diagnostic procedures and clinico-radiological findings of acute fibrinous and organizing pneumonia: a systematic review and pooled analysis.European radiology · 2021Pooled it
- Acute Fibrinous and Organizing Pneumonia Versus Organizing Pneumonia: A Comparative Study of Clinical, Radiological, Histological, and Immunophenotypic Features.Journal of clinical medicine · 2026Article
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Disease: Cryptogenic Organizing Pneumonia.Tuberculosis and respiratory diseases · 2025Article
- Clinicopathologic Features of Isolated AFOP Nodules Radiologically Mimicking Malignancy in Post COVID-19 Patients: A Case Series Study.Journal of clinical medicine · 2025Article
- Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report.Experimental and therapeutic medicine · 2025Article
- Diagnostic value of CT radiomics and clinical features in differentiating focal organizing pneumonia from peripheral lung cancer.Frontiers in oncology · 2025Article
- Acute Fibrinous and Organizing Pneumonia (AFOP) in Children: A Case Report and Literature Review.Pediatric health, medicine and therapeutics · 2025Article
- Everolimus Induced Acute Fibrinous and Organizing Pneumonia (AFOP): A Rare Case Report.Case reports in pulmonology · 2025Article
- Acute fibrinous and organizing pneumonia associated with Candida: A case report.Respiratory medicine case reports · 2024Article
- Cell-Type Apoptosis in Lung during SARS-CoV-2 Infection.Pathogens (Basel, Switzerland) · 2021Article
- Clinical manifestation, laboratory and radiology finding, treatment and outcomes of COVID-19: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.Critical care (London, England) · 2020Article
- A case report of fungal infection associated acute fibrinous and organizing pneumonitis.BMC pulmonary medicine · 2020Review
- A Rare Case of Acute Fibrinous Organizing Pneumonia in a Patient With Post-obstructive Pneumonia and Malignancy.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute Fibrinous and Organizing Pneumonitis (AFOP) is a disease with histopathological pattern characterized by the presence of intra-alveolar fibrin in the form of fibrin "balls" and organizing pneumonia represented by inflammatory myofibroblastic polyps. Symptoms of this rare interstitial pulmonary disease can be either acute or sub-acute and it can rapidly progress to death. Diagnosis should be considered in the Intensive Care Unit (ICU) if patients' symptomatology and radiology correlates with non-responding or progressive pneumonia and when morphology, on biopsies, encompasses criteria of diffuse alveolar damage (DAD) and organizing pneumonia (OP) balancing in between. Three clinical cases of patients presenting severe lung disease requiring mechanical ventilation and prolonged intensive care fitted on the variable spectra of AFOP histopathology and had poor outcome: a 23 year-old women had AFOP in the context of antiphospholipid syndrome pulmonary compromise; a 35 year-old man developed a letal intensive care pneumonia with AFOP pattern registered in post-mortem biopsy; and a 79 year-old man died 21 days after intensive care unit treatment of a sub-pleural organizing pneumonia with intra-alveolar fibrin, seen in post-mortem biopsy. The predominance of acute fibrin alveolar deposition pattern is helpful in raising AFOP differential diagnosis while organizing pneumonia pattern establishes a wider range of diagnosis that can go till solitary pulmonary nodule, remaining indefinite to suggest diagnosis. The performance time of biopsy in a larger number of clinical cases may be helpful in establishing the evolutionary morphological pattern, taking in mind the poor outcome of the disease, deserving rapid diagnosis to define treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.