Evidence map›Paper›PMID 31075852›Full record

ArticleInternational journal of molecular sciences2019

Molecular Characterization, Bioinformatic Analysis, and Expression Profile of Lin-28 Gene and Its Protein from Arabian Camel (

Sultan N Alharbi, Ibtehal S Alduhaymi, Lama Alqahtani, Musaad A Altammaami, Fahad M Alhoshani, Deema K Alrabiah, Saleh O Alyemni, Khulud A Alsulami, Waleed M Alghamdi, Mohannad Fallatah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Genomic Analysis of Intrinsically Disordered Proteins in the GenusInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sultan N AlharbiNational Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia. snharbi@kacst.edu.sa.ORCID 0000-0002-5232-3165
Ibtehal S AlduhaymiNational Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia. ialduhaymi@kacst.edu.sa.
Lama AlqahtaniNational Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia. lalqahtani@kacst.edu.sa.
Musaad A AltammaamiNational Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. mtammami@kacst.edu.sa.
Fahad M AlhoshaniNational Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. fhoshani@kacst.edu.sa.
Deema K AlrabiahNational Center for Pharmaceutical Technology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. dalrabiah@kacst.edu.sa.
Saleh O AlyemniNational Center for Pharmaceutical Technology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. saleh.o.alyemni@hotmail.com.
Khulud A AlsulamiNational Center for Pharmaceutical Technology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. kaalsulami@kacst.edu.sa.
Waleed M AlghamdiNational Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia. wghamdi@kacst.edu.sa.
Mohannad FallatahNational Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia. mfallatah@kacst.edu.sa.
King Abdulaziz City for Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lin-28 is an RNA-binding protein that is known for its role in promoting the pluripotency of stem cells. In the present study, Arabian camel Lin-28 (cLin-28) cDNA was identified and analyzed. Full length cLin-28 mRNA was obtained using the reverse transcription polymerase chain reaction (RT-PCR). It was shown to be 715 bp in length, and the open reading frame (ORF) encoded 205 amino acids. The molecular weight and theoretical isoelectric point (pI) of the cLin-28 protein were predicted to be 22.389 kDa and 8.50, respectively. Results from the bioinformatics analysis revealed that cLin-28 has two main domains: an N-terminal cold-shock domain (CSD) and a C-terminal pair of retroviral-type Cysteine3Histidine (CCHC) zinc fingers. Sequence similarity and phylogenetic analysis showed that the cLin-28 protein is grouped together

Indexed as

Gene Expression ProfilingAmino Acid SequenceAnimalsBase SequenceCamelusComputational BiologyGene Expression RegulationModels, MolecularPeptidesPhylogenyProtein Structure, SecondaryRNA-Binding ProteinsRNA, MessengerPeptidesRNA-Binding ProteinsRNA, Messenger3D structureArabian Camelbioinformatics analysiscold-shock domain (CSD)Lin-28phylogenetic analysisPMF-MS

Identifiers

PMID31075852
PMCPMC6540139
OpenAlexW2944720245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.