Evidence map›Paper›PMID 31075839›Full record

ArticleCancers2019

Acute Tumor Transition Angle on Computed Tomography Predicts Chromosomal Instability Status of Primary Gastric Cancer: Radiogenomics Analysis from TCGA and Independent Validation.

Ying-Chieh Lai, Ta-Sen Yeh, Ren-Chin Wu, Cheng-Kun Tsai, Lan-Yan Yang, Gigin Lin, Michael D Kuo

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. TCGA-TCIA Impact on Radiogenomics Cancer Research: A Systematic Review.International journal of molecular sciences · 2019
    Pooled it
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ying-Chieh LaiDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan. cappolya@gmail.com.
Ta-Sen YehDepartment of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan. tsy471027@cgmh.org.tw.
Ren-Chin WuDepartment of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan. renchin.wu@gmail.com.ORCID 0000-0003-1439-0874
Cheng-Kun TsaiImaging Core Lab, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan. klem.tsaick@gmail.com.
Lan-Yan YangClinical Trial Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. lyyang0111@gmail.com.
Gigin LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan. giginlin@cgmh.org.tw.ORCID 0000-0001-7246-1058
Michael D KuoDepartment of Diagnostic Radiology, University of Hong Kong, Hong Kong 999077, China. mikedkuo@gmail.com.
Chang Gung University · TWChang Gung Memorial Hospital · TWUniversity of Hong Kong · HK

Funding

Chang Gung Medical Foundation CMRPG3E1321-2 and IRB201601916B0, IRB103-7448BMinistry of Science and Technology, Taiwan 106-2314-B-182A-019-MY3
6 · The paper itself

Abstract

Chromosomal instability (CIN) of gastric cancer is correlated with distinct outcomes. This study aimed to investigate the role of computed tomography (CT) imaging traits in predicting the CIN status of gastric cancer. We screened 443 patients in the Cancer Genome Atlas gastric cancer cohort to filter 40 patients with complete CT imaging and genomic data as the training cohort. CT imaging traits were subjected to logistic regression to select independent predictors for the CIN status. For the validation cohort, we prospectively enrolled 18 gastric cancer patients for CT and tumor genomic analysis. The imaging predictors were tested in the validation cohort using receiver operating characteristic curve (ROC) analysis. Thirty patients (75%) in the training cohort and 9 patients (50%) in the validation cohort had CIN subtype gastric cancers. Smaller tumor diameter (

Indexed as

chromosomal instabilitycomputed tomographygastric cancermorphologyradiogenomics

Identifiers

PMID31075839
PMCPMC6562475
OpenAlexW2944451811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.