ArticleBrain and language2019
A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia.
Article in Brain and language, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum.NeuroImage · 2026Review
- Rethinking anomia across the frontotemporal dementia spectrum: marker of language dysfunction or global cognitive decline?medRxiv : the preprint server for health sciences · 2026Article
- Connected Speech Alterations and Progression in Patients With Primary Progressive Aphasia Variants.Neurology · 2025Article
- Investigating changes in connected speech in nonfluent/agrammatic primary progressive aphasia following script training.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions.Frontiers in aging neuroscience · 2025Article
- Advancing Neuropsychological Rehabilitation in Primary Progressive Aphasia Based on Principles of Cognitive Neuroscience: A Scoping Review and Systematic Analysis of the Data.Brain sciences · 2024Article
- Toolkit to Examine Lifelike Language (TELL): An app to capture speech and language markers of neurodegeneration.Behavior research methods · 2024Article
- Communicative impairment and its neural correlates in Alzheimer's disease and frontotemporal dementia.Brain and behavior · 2024Article
- Behavioral variant frontotemporal dementia associated with GRN and ErbB4 gene mutations: a case report and literature review.BMC medical genomics · 2024Review
- Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.Neurology · 2024Article
- The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.Frontiers in aging neuroscience · 2024Article
- Speech and language markers of neurodegeneration: a call for global equity.Brain : a journal of neurology · 2023Review
- Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023Review
- Developing a Memory and Communication App for Persons Living With Dementia: An 8-Step Process.JMIR aging · 2023Article
- Spared speech fluency is associated with increased functional connectivity in the speech production network in semantic variant primary progressive aphasia.Brain communications · 2023Article
- Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia.Brain communications · 2023Article
- The natural history of primary progressive aphasia: beyond aphasia.Journal of neurology · 2022Article
- [Preliminary study of the temporal variables of continuous speech in patients with neurodegenerative syndromes of the frontotemporal lobar degeneration spectrum].Revista de neurologia · 2022Article
- Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We examined longitudinal change in language expression during a semi-structured speech sample in 48 patients with primary progressive aphasia (PPA) or behavioral variant frontotemporal dementia (bvFTD) and related this to longitudinal neuroimaging of cortical thickness available in 25 of these patients. All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD. These patient groups also declined on several neuropsychological measures, but there was no correlation between decline in speech expression and decline in neuropsychological performance. Longitudinal decline in grammaticality, assessed by the number of well-formed sentences produced, was associated with longitudinal progression of gray matter atrophy in left frontal operculum/insula and bilateral temporal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.