Evidence map›Paper›PMID 31075202›Full record

ArticleNano letters2019

Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics.

Robert D Viveros, Tao Zhou, Guosong Hong, Tian-Ming Fu, Hao-Yu Greg Lin, Charles M Lieber

Abstract read
In one paragraph

Article in Nano letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  5. Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  6. Review
  7. A Soft, High-Density Neuroelectronic Array.Npj flexible electronics · 2023
    Article
  8. Review
  9. Article
  10. Developing Precision Invasive Neuromodulation for Psychiatry.The Journal of neuropsychiatry and clinical neurosciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert D Viveros
Tao Zhou
Guosong Hong
Tian-Ming Fu
Hao-Yu Greg Lin

Funding

Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous SystemDP1EB025835 · NIBIB · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2019
$3.5M
Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable ElectronicsR00AG056636 · NIA · STANFORD UNIVERSITY · PI HONG, GUOSONG · 2018 to 2020
$745k
Syringe Injectable Electronics Platform for Chronic Mapping and Modulation of Neural Circuits in AddictionR21DA043985 · NIDA · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2018
$436k
Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable ElectronicsK99AG056636 · NIA · HARVARD UNIVERSITY · PI HONG, GUOSONG · 2017 to 2018
$255k
NIA NIH HHS K99 AG056636NIA NIH HHS R00 AG056636NIBIB NIH HHS DP1 EB025835NIDA NIH HHS R21 DA043985
6 · The paper itself

Abstract

The unique structure and mechanical properties of syringe-injectable mesh electronics have enabled seamless tissue integration and stable chronic recording of the activities of the same neurons on a year scale. Here, we report studies of a series of structural and mechanical mesh electronics design variations that allow injection using needles at least 4-fold smaller than those previously reported to minimize the footprint during injection of the electronics in soft matter and tissue. Characterization of new ultraflexible two-dimensional (2D) and one-dimensional (1D) probes has demonstrated reproducible injection of the newly developed mesh electronics designs via needles as small as 100 μm in inner diameter (ID) with reduced injection volumes. In vitro hydrogel and in vivo mouse brain studies have shown that ultraflexible 2D and 1D probes maintain their structural integrity and conformation post-injection after being transferred through the reduced diameter needles. In addition, analysis of the variation of the post-injection mesh cross sections suggests a smaller degree of tissue deformation and relaxation with decreasing needle diameters. The capability to implement rational design for mesh electronic probes that can be delivered via much smaller diameter needles should open up new opportunities for integration of electronics with tissue and soft matter in fundamental and translational studies.

Indexed as

PliabilityAnimalsBiomimetic MaterialsBrainElectronics, MedicalEquipment DesignInjectionsMiceNeedlesNeuronsProstheses and Implantsminimal footprintone-dimensional probesoft material integrationTissue-like electronicsultraflexible probeultrasmall needle

Identifiers

PMID31075202
PMCPMC6565464

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.