Evidence map›Paper›PMID 31075129›Full record

ArticlePloS one2019

Peak urea level, leukocyte count and use of invasive ventilation as risk factors of mortality in acute pancreatitis: A retrospective study.

Chao-Nan Liu, Si Chen, Hao Chen, Li Yue, Li-Qin Ling, Chang-Wei Chen, Lei Du, Jing Zhou

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chao-Nan LiuDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Si ChenDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Hao ChenDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Li YueWorkplace Safety & Insurance Board, Toronto, Ontario, Canada.
Li-Qin LingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Chang-Wei ChenDepartment of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Lei DuDepartment of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Jing ZhouDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-4251-9068
Sichuan University · CNWorkplace Safety & Insurance Board · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is associated with high complications. Early, reliable prediction of mortality may improve patient management.

methodsWe retrospectively reviewed medical records of 1,599 patients with AP treated at a single large hospital in southwest China. Models to predict mortality were derived from a subset of 1,062 patients (development dataset), and the models were then validated in the remaining 537 patients (validation dataset). Independent risk factors and prediction models for mortality were identified using logistic regression.

resultsA total of 33 patients in the development dataset and 13 in the validation dataset died during hospitalization. Independent risk factors for mortality were found to be plasma urea levels, glucose levels and platelet counts at admission; as well as peak urea levels, leukocyte counts and use of invasive ventilation during hospitalization. Based on the development dataset, a mortality prediction model based only on urea level at admission gave an area under the curve (AUC) of 0.81, which did not significantly improve by incorporating glucose level or platelet count at admission. Significantly better was a model taking into account three in-hospital parameters: peak urea level, leukocyte count and use of invasive ventilation (AUC 0.97).

conclusionsWhile mortality of AP patients can be predicted reasonably well based only on urea values at admission, predictions are more reliable when they take into account in-hospital data on peak urea level, leukocyte count and use of invasive ventilation.

Indexed as

AdultAgedChinaFemaleHospital MortalityHumansLeukocyte CountLogistic ModelsMaleMiddle AgedModels, TheoreticalPancreatitisPatient AdmissionRespiration, ArtificialRetrospective StudiesRisk AssessmentUrea

Identifiers

PMID31075129
PMCPMC6510417
OpenAlexW2944801501

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.