Evidence map›Paper›PMID 31075059›Full record

Trial reportThe Journal of urology2019

A Randomized Controlled Trial of Device Guided, Slow-Paced Respiration in Women with Overactive Bladder Syndrome.

Alison J Huang, Deborah Grady, Wendy B Mendes, Cesar Hernandez, Michael Schembri, Leslee L Subak

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alison J HuangDepartment of Medicine, University of California-San Francisco, San Francisco.
Deborah GradyDepartment of Medicine, University of California-San Francisco, San Francisco.
Wendy B MendesDepartment of Psychiatry, University of California-San Francisco, San Francisco.
Cesar HernandezDepartment of Medicine, University of California-San Francisco, San Francisco.
Michael SchembriDepartment of Obstetrics, Gynecology and Reproductive, University of California-San Francisco, San Francisco.
Leslee L SubakDepartment of Obstetrics and Gynecology, Stanford University, Stanford, California.
University of California, San Francisco · USGTx (United States) · USStanford University · US

Funding

A Behavioral Slow-Breathing Exercise Program for Female Overactive BladderR01AG047894 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2014 to 2017
$1.8M
Patient Oriented Research and Mentoring in Obesity and Urinary IncontinenceK24DK080775 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUBAK, LESLEE L · 2008 to 2019
$1.7M
Nocturnal overactive bladder and sleep disruption in middle-aged and older womenR03AG056752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2017 to 2018
$159k
NIA NIH HHS R01 AG047894NIA NIH HHS R03 AG056752NIDDK NIH HHS K24 DK080775
6 · The paper itself

Abstract

purposeWe evaluated the effects of device guided, slow-paced respiration on urgency associated urinary symptoms, perceived stress and anxiety, and autonomic function in women with overactive bladder syndrome. MATERIALS AND

methodsWe performed a randomized, parallel group trial of slow-paced respiration to improve perceived stress and autonomic dysfunction as potential contributors to overactive bladder. Ambulatory women who reported at least 3 voiding or incontinence episodes per day associated with moderate to severe urgency were randomized to use a portable biofeedback device to practice daily, slow, guided breathing exercises or a control device which appeared identical and was reprogrammed to play music without guiding breathing. During 12 weeks we evaluated changes in urinary symptoms by voiding diaries, perceived stress and anxiety by validated questionnaires, and autonomic function by heart rate variability and impedance cardiography.

resultsIn the 161 randomized participants, including 79 randomized to paced respiration and 82 randomized to the control group, the average ± SD baseline frequency of voiding or incontinence associated with moderate to severe urgency was 6.9 ± 3.4 episodes per day. Compared to controls the participants randomized to paced respiration demonstrated greater improvement in perceived stress (average Perceived Stress Scale score decrease 2.8 vs 1.1, p=0.03) but not in autonomic function markers. During 12 weeks the average frequency of voiding or incontinence associated with moderate to severe urgency, which was the study primary outcome, decreased by a mean of 0.9 ± 3.2 episodes per day but no significant between group difference was detected.

conclusionsAmong women with overactive bladder slow-paced respiration was associated with a modest improvement in perceived stress during 12 weeks. However, it was not superior to a music listening control for reducing urinary symptoms or changing autonomic function.

Indexed as

AgedBreathing ExercisesFemaleHumansMiddle AgedRelaxationRespiratory RateStress, PsychologicalTreatment OutcomeUrinary Bladder, OveractiveUrinationautonomic nervous systembreathing exercisesoveractivepsychologicalrelaxation therapystressurinary bladder

Identifiers

PMID31075059
PMCPMC6842393
OpenAlexW2944441877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.