Evidence map›Paper›PMID 31074835›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2019

A community-based, cross-sectional study of hrHPV DNA self-sampling-based cervical cancer screening in rural Karnataka, India.

Prajakta Adsul, Vijaya Srinivas, Savitha Gowda, Shivamma Nayaka, Rashmi Pramathesh, Kavitha Chandrappa, Anisa Khan, Poornima Jayakrishna, Purnima Madhivanan

Abstract read
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Comment on Self-Sampling Methodology Impression for Cervical Cancer Screening.Asian Pacific journal of cancer prevention : APJCP · 2023
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  15. Building Capacity for Global Cancer Research: Existing Opportunities and Future Directions.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Prajakta AdsulImplementation Science team, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
Vijaya SrinivasPublic Health Research Institute of India, Mysore, Karnataka, India.
Savitha GowdaPublic Health Research Institute of India, Mysore, Karnataka, India.
Shivamma NayakaPublic Health Research Institute of India, Mysore, Karnataka, India.
Rashmi PramatheshPublic Health Research Institute of India, Mysore, Karnataka, India.
Kavitha ChandrappaPublic Health Research Institute of India, Mysore, Karnataka, India.
Anisa KhanPublic Health Research Institute of India, Mysore, Karnataka, India.
Poornima JayakrishnaPublic Health Research Institute of India, Mysore, Karnataka, India.
Purnima MadhivananPublic Health Research Institute of India, Mysore, Karnataka, India.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338Fogarty International Center at the National Institutes of Health
6 · The paper itself

Abstract

objectiveTo examine the feasibility of implementing a high-risk HPV (hrHPV) DNA-based screening program for cervical cancer and the prevalence of hrHPV DNA-positive women in a community setting in rural India.

methodsA cross-sectional study was conducted at the community level in the Hunsur taluk of the Mysore district from January to August 2016. Cervical cancer screening was conducted with self-collected vaginal samples that were analyzed using the Hybrid Capture 2 (HC2) assay (Qiagen, USA).

resultsThe majority of participants were aged 30-39 years, with no formal schooling, from a lower caste, and lived below an annual household income of US$1499. After group health education and one-on-one counseling, a total of 473 women underwent self-sampling. Of these, 36 (7.6%) were positive for hrHPV and only 24 (66.6%) underwent follow-up diagnostic triaging. Cancer was detected in two women, who were referred to appropriate healthcare facilities for further treatment.

conclusionImplementation of hrHPV DNA-based screening tests using self-sampling can be feasible in rural settings in India. However, substantial resources are required for providing health education and one-on-one counseling to inform asymptomatic women about the benefits of testing and, more importantly, to improve compliance with follow-up.

Indexed as

AdultCross-Sectional StudiesDNA, ViralEarly Detection of CancerFemaleHumansIndiaMass ScreeningMiddle AgedPapillomavirus InfectionsPregnancyPrevalenceSurveys and QuestionnairesUterine Cervical NeoplasmsVaginal SmearsDNA, ViralCervical cancerCross-sectional studyDemonstration studyHPV DNAImplementationScreeningSelf-sampling

Identifiers

PMID31074835
PMCPMC6620767

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.