ArticleJAMA network open2019
Risk and Risk Factors Associated With Recurrent Venous Thromboembolism Following Surgery in Patients With History of Venous Thromboembolism.
Article in JAMA network open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recurrent VTE in patients with thrombophilia after stopping anticoagulation: a systematic review and meta-analysis.Blood advances · 2026Pooled it
- Clinical characteristics, management strategies, and outcomes in patients with preoperative venous thromboembolism who underwent surgery: survey data from 2020 to 2022 by the Japanese Society of Anesthesiologists.Journal of anesthesia · 2026Article
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- Article
- Does Surgical Treatment of Varicose Veins Prior to Total Knee Arthroplasty Decrease Rates of Postoperative Venous Thromboembolism? A Matched Cohort Study.Journal of orthopaedics · 2025Article
- Article
- Predicting short-term thromboembolic risk following Roux-en-Y gastric bypass using supervised machine learning.World journal of gastrointestinal surgery · 2024Article
- While the Incidence of Venous Thromboembolism After Shoulder Arthroscopy Is Low, the Risk Factors Are a Body Mass Index Greater than 30 and Hypertension.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- A Comprehensive Review of Risk Factors and Thrombophilia Evaluation in Venous Thromboembolism.Journal of clinical medicine · 2024Review
- Development and Validation of an ICU-Venous Thromboembolism Prediction Model Using Machine Learning Approaches: A Multicenter Study.International journal of general medicine · 2024Article
- Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study.Langenbeck's archives of surgery · 2023Article
- Risk factors for patients with acute hospital-acquired symptomatic pulmonary thromboembolism.Scientific reports · 2023Article
- Article
- Prevalence of Venous Thromboembolism in Intensive Care Units: A Meta-Analysis.Journal of clinical medicine · 2022Review
- Time trends in the incidence rates of venous thromboembolism following colorectal resection by indication and operative technique.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- The Safety and Efficacy of Apixaban (Eliquis) in 5017 Post-bariatric Patients with 95.3% Follow-up: a Multicenter Study.Obesity surgery · 2022Article
- Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors.Advanced healthcare materials · 2022Article
- Risk factors for venous thromboembolism following fractures isolated to the foot and ankle fracture.PloS one · 2022Article
- Current Knowledge on Factor V Leiden Mutation as a Risk Factor for Recurrent Venous Thromboembolism: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Article
- Challenges in evaluating treatments for COVID-19: The case of in-hospital anticoagulant use and the risk of adverse outcomes.Frontiers in pharmacology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: The size of the risk of recurrent venous thromboembolism (VTE) after surgery in patients with a history of VTE is not well known. Objectives: To estimate the risk of and to identify the factors associated with recurrent VTE in patients undergoing surgery who have a history of VTE. Design, Setting, and Participants: This population-based, follow-up cohort study includes patients with VTE who participated in the Multiple Environment and Genetic Assessment (MEGA) study. Original data were collected from March 1999 to April 2010. Data analysis began in June 1999 and ended in April 2010. Exposures: Surgery following a first VTE. Main Outcomes and Measurements: Kaplan-Meier analyses were used to estimate cumulative incidences of recurrent VTE. Cox regression with a time-dependent covariate (surgery) was used to calculate the hazard ratio (HR) for developing recurrent VTE after surgery compared with no surgery. Results: Overall, 3741 patients (mean [SD] age, 48.4 [12.8] years; 2020 [54.0%] women) with a history of VTE were included in the analysis, amounting to 18 899 person-years, with a median (interquartile range) follow-up of 5.7 (3.0-7.2) years. Of the 3741 patients, 580 (15.5%) underwent surgery and 601 (16.1%) developed a recurrent thrombotic event. The 1-month cumulative incidence of recurrent VTE for all surgery types was 2.1% (95% CI, 1.2%-3.6%), which increased to 3.3% (95% CI, 2.1%-5.1%) at 3 months and 4.6% (95% CI, 3.1%-6.6%) at 6 months. At 6 months, risk of recurrent VTE ranged from 2.3% to 9.3%, depending on surgery type. In addition to surgery type, factor V Leiden mutation (HR, 3.4; 95% CI, 1.6-7.4) and male sex (HR, 2.7; 95% CI, 1.3-5.8) were associated with increased risk of recurrent VTE. Conclusions and Relevance: Surgery was associated with an increased risk of recurrent VTE in patients with a history of VTE; risk remained high for up to 6 months after the procedure. This study suggests that high-risk individuals may be identified based on surgery type, sex, and the presence of factor V Leiden mutation. These findings stress the need for revision of the current thromboprophylactic approach to prevent recurrence in these patients.
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