ArticleeLife2019
Self-organized reactivation maintains and reinforces memories despite synaptic turnover.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 77 citations in OpenAlex.
- Two-factor synaptic plasticity enables memory consolidation during neuronal burst firing.PNAS nexus · 2026Article
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- Statistics of cortical representational drift can enable robust readout.PLoS computational biology · 2026Article
- Article
- Formation of an expanding memory representation in the hippocampus.Nature neuroscience · 2025Article
- Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP.PLoS computational biology · 2025Article
- Autonomous retrieval for continuous learning in associative memory networks.Frontiers in computational neuroscience · 2025Article
- Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.The European journal of neuroscience · 2024Article
- Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.Annual review of neuroscience · 2024Review
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Cortical cell assemblies and their underlying connectivity: An in silico study.PLoS computational biology · 2024Article
- Article
- A dynamic attractor network model of memory formation, reinforcement and forgetting.PLoS computational biology · 2023Article
- Synaptic weights that correlate with presynaptic selectivity increase decoding performance.PLoS computational biology · 2023Article
- Purely STDP-based assembly dynamics: Stability, learning, overlaps, drift and aging.PLoS computational biology · 2023Article
- Controlling neuronal assemblies: a fundamental function of respiration-related brain oscillations in neuronal networks.Pflugers Archiv : European journal of physiology · 2023Review
- Small, correlated changes in synaptic connectivity may facilitate rapid motor learning.Nature communications · 2022Article
- Stochastic consolidation of lifelong memory.Scientific reports · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Long-term memories are believed to be stored in the synapses of cortical neuronal networks. However, recent experiments report continuous creation and removal of cortical synapses, which raises the question how memories can survive on such a variable substrate. Here, we study the formation and retention of associative memory in a computational model based on Hebbian cell assemblies in the presence of both synaptic and structural plasticity. During rest periods, such as may occur during sleep, the assemblies reactivate spontaneously, reinforcing memories against ongoing synapse removal and replacement. Brief daily reactivations during rest-periods suffice to not only maintain the assemblies, but even strengthen them, and improve pattern completion, consistent with offline memory gains observed experimentally. While the connectivity inside memory representations is strengthened during rest phases, connections in the rest of the network decay and vanish thus reconciling apparently conflicting hypotheses of the influence of sleep on cortical connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.