Evidence map›Paper›PMID 31074702›Full record

ArticlePhysiological genomics2019

Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.

Haocheng Lu, Jinjian Sun, Wenying Liang, Jifeng Zhang, Oren Rom, Minerva T Garcia-Barrio, Shengdi Li, Luis Villacorta, Francisco J Schopfer, Bruce A Freeman and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. CD73Nature communications · 2026
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  5. Lipoxin AbioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Haocheng LuFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Jinjian SunFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Wenying LiangFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Jifeng ZhangFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Oren RomFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Minerva T Garcia-BarrioFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Shengdi LiGenome Biology Unit, European Molecular Biology Laboratory (EMBL) , Heidelberg , Germany.
Luis VillacortaFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania.
Y Eugene ChenFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
Yanbo FanFrankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center , Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USUniversity of Pittsburgh · USEuropean Molecular Biology Laboratory · DE

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
The Role of PPAR-gamma in Vascular Lesion FormationR01HL068878 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2002 to 2019
$7.6M
Redox-Derived Pulmonary Anti-Inflammatory MediatorsR01HL064937 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2000 to 2015
$5.6M
Redox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2M
Formation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4M
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9M
Kruppel-like factor 11 (KLF11) and atherosclerosisR01HL138139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2017 to 2021
$2.3M
The Role of TM6SF2 in Cardiovascular DiseaseR01HL137214 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2020
$2.2M
The role of TFEB in aortic aneurysmsR01HL145176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2019 to 2022
$2.2M
Transcription Factor-EB and Postischemic AngiogenesisR01HL138094 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2017 to 2021
$2.2M
Conjugated linoleic acid nitration in vascular inflammation and atherosclerosisR01HL123333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VILLACORTA, LUIS · 2015 to 2019
$2.0M
Predominant protective role in hepatic steatosis and obesity by fish oil-derived furansR01DK112854 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL064937NHLBI NIH HHS R01 HL068878NHLBI NIH HHS R01 HL123333NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R01 HL137214NHLBI NIH HHS R01 HL138094NHLBI NIH HHS R01 HL138139NHLBI NIH HHS R01 HL145176NHLBI NIH HHS R37 HL058115NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK112854NIGMS NIH HHS R01 GM125944
6 · The paper itself

Abstract

Endothelial cell (EC) dysfunction is a crucial initiation event in the development of atherosclerosis and is associated with diabetes mellitus, hypertension, and heart failure. Both digestive and oxidative inflammatory conditions lead to the endogenous formation of nitrated derivatives of unsaturated fatty acids (FAs) upon generation of the proximal nitrating species nitrogen dioxide (·NO

Indexed as

AdultCardiovascular SystemCells, CulturedEndothelial CellsGene Regulatory NetworksHomeostasisHumansInflammationLinoleic Acids, ConjugatedMaleNitric OxideOxidative StressTranscriptomeLinoleic Acids, ConjugatedNitric Oxideconjugated linoleic acidendothelial cellnitroalkenenitro-fatty acidRNA-Seq

Identifiers

PMID31074702
PMCPMC6620647
OpenAlexW2943966114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.