ArticleJournal of clinical laboratory analysis2019
The association between IL-17A and IL-23R polymorphisms and coronary artery disease risk in a Middle Eastern Chinese population.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- A Common Genetic Background for Psoriasis and Cardiovascular Diseases: A Narrative Review.Health science reports · 2025Article
- Cardiovascular Considerations and Implications for Treatment in Psoriasis: An Updated Review.Vascular health and risk management · 2024Review
- Interleukin-17 as a key player in neuroimmunometabolism.Nature metabolism · 2023Review
- Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways.International journal of molecular sciences · 2022Review
- Glycosylated hemoglobin A1c predicts coronary artery disease in non-diabetic patients.Journal of clinical laboratory analysis · 2021Article
- Gene Expression Analysis Suggests Immunological Changes of Peripheral Blood Monocytes in the Progression of Patients With Coronary Artery Disease.Frontiers in genetics · 2021Article
- Association study between rs2275913 genetic polymorphism and serum levels of IL-17A with risk of coronary artery disease.Molecular biology research communications · 2020Article
- The association between IL-17A and IL-23R polymorphisms and coronary artery disease risk in a Middle Eastern Chinese population.Journal of clinical laboratory analysis · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms in IL-17A and IL-23R may affect the expression of these genes and could contribute to a patient's susceptibility to coronary artery disease (CAD). Although this association was investigated by previous studies, the relationship remains unclear.
methodWe conducted this hospital-based case-control study to determine whether polymorphisms in these two genes could be associated with a risk of CAD. A total of 191 patients and 131 controls, as determined by SXscore, were enrolled in this study. The genotyping was performed with the Sequenom MassARRAY platform.
resultsThe results showed that that the FPG and HbA1C levels were higher in patients with CAD than in the controls. In addition, the HDL and ApoA1 levels were significantly higher in the controls than in the cases. In contrast, the Lp(a) level was significantly lower in the controls than in the patients. The IL-17A rs2275913 and IL-23R rs6682925 polymorphisms were associated with an increased risk of CAD (rs2275913: AA vs GG: crude OR = 2.16, 95% CI = 1.08-4.30; AG/AA vs GG: crude OR = 1.81, 95% CI = 1.04-3.15; rs6682925 CC vs TT: crude OR = 1.91, 95% CI = 1.00-3.63). The subgroup analysis by SXscore revealed that the IL-23R rs6682925 polymorphism (CT/CC vs TT: crude OR = 3.72, 95% CI = 1.19-11.66) was associated with an increased risk of CAD in patients with a high SXscore.
conclusionThis study suggested that T2DM, Lp(a), HDL-c, and ApoA1 were risk factors of CAD and that the IL-17A rs2275913 and IL-23R rs6682925 polymorphisms may contribute to susceptibility to CAD.
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