ArticleBMC surgery2019
Postoperative hypocalcemia: analysis of factors influencing early hypocalcemia development following thyroid surgery.
Article in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy.Frontiers in oncology · 2020Pooled it
- Thyroidectomy under local versus general anesthesia in health camp settings in Uganda: a randomized prospective equivalence single-blind controlled trial.BMC surgery · 2025Trial
- Article
- Modeling the Relationship of Age With Hypocalcemia Following Total Thyroidectomy: A NSQIP Analysis.Laryngoscope investigative otolaryngology · 2026Article
- Artificial intelligence for predicting transient hypocalcemia after total thyroidectomy.Scientific reports · 2026Article
- Nomogram to predict the early postoperative hypoparathyroidism after total thyroidectomy in the thyroid cancer patients of eastern China.Gland surgery · 2026Article
- Symptom clusters and contemporaneous symptom network analysis at discharge in patients with differentiated thyroid cancer after thyroidectomy.Endocrine · 2026Article
- Incidence and Risk Factors for Post-Thyroidectomy Hypocalcemia:Saudi medical journal · 2026Article
- Predicting Hypocalcemia and Identifying Supplementation Needs After Total Thyroidectomy: The Role of Perioperative PTH Measurements.Biomedicines · 2025Article
- Standardizing the reporting of postoperative hypoparathyroidism following thyroidectomy: consensus statement from the European Society of Endocrine Surgeons, the American Association of Endocrine Surgeons, and the International Association of Endocrine Surgeons.The British journal of surgery · 2025Article
- A Rare Presentation of Hypocalcaemia-Induced Seizure Secondary to Late-Onset Post-Thyroidectomy Complication.Cureus · 2025Article
- Progress and Outcomes of Intraoperative Nerve Monitoring During Thyroidectomy.JAMA otolaryngology-- head & neck surgery · 2025Article
- Article
- Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study.Scientific reports · 2025Article
- Gastrointestinal surgery, malabsorptive conditions, and postoperative hypocalcemia after neck surgery.Surgery · 2025Article
- Review
- Acute severe hypocalcaemia after initiation of a selective RET-inhibitor in medullary thyroid cancer.Endocrine oncology (Bristol, England) · 2025Article
- Post-thyroidectomy hypoparathyroidism: A clinical surgical dilemma.Saudi medical journal · 2024Review
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly Hypocalcemia is the most frequent complication after thyroid surgery. Several studies have tried to identify factors (patient caracteristics or surgical technique variations) affecting hypocalcemia following thyroid surgery. This studiy evaluates the role of several factors in postoperative hypocalcemia development.
methodsA retrospective study conducted on 2108 patients that underwent thyroid surgery in a single center (1669 women and 439 men). Postoperative early hypocalcemia was defined as serum calcium levels lower than 8,0 mg/dl measured 24 h after surgery. Following factors were evaluated in the study: sex, age, glandular hyperfunction, preoperative diagnosis, preoperative serum calcium levels, preoperative serum PTH levels, type of surgery performed (total thyroidectomy vs. lobectomy); minimally invasive video assisted thyroidectomy (MIVAT); number of parathyroid preserved in situ, postoperative serum calcium levels, changes in perioperative calcium levels (difference between preoperative values and postoperative calcium levels), presence of carcinoma in the surgical specimen, presence of thyroiditis based on histopatology reports.
resultsAmong evaluated factors only gender and surgical procedure revealed to be significantly correlated to early hypocalcemia development. In fact female patients experienced postoperative hypocalcemia in 42% (701/1669) of cases, which was signicantly higher than the 21.4% (94/439) identified in men. We also noticed a greater hypocalcemia incidence in patient undergoing total thyroidectomy (38.8%) than in patient undergoing lobectomy group (13.8%). Early hypocalcemia development didn't appear to be related to preoperative serum calcium levels but it showed a statistically significant correlation with perioperative serum calcium level drop.
conclusionThis findings suggest that sex (female gender is a strong risk factor),surgical procedure and perioperative changes in serum calcium are the only factors (among all variables examined) that influence early hypocalcemia development.
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