ArticleJournal of enzyme inhibition and medicinal chemistry2019
Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study.
Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
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- Variability in seed oil content, fatty acids profile, phytochemical properties, mineral and proximate composition of Iranian cultivars of vitis vinifera L.Scientific reports · 2025Article
- Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1.Redox biology · 2025Article
- Optimum concentrations of potassium and zinc for better performance, nutritional, and biochemical quality of hydroponically cultivated Spinacia oleracea Cv. Virofly.Scientific reports · 2025Article
- Phytochemical profiling, antioxidant potential, and UHPLC-HRMS analysis of Phlomis genus aerial parts for therapeutic applications.Scientific reports · 2025Article
- Chemometrics based analysis of the essential oil composition, phenolic compounds and antibacterial potency of aerial parts of Grammosciadium platycarpum populations.Scientific reports · 2025Article
- Chemometrics-based analysis of the phytochemical profile and antioxidant activity of Salvia species from Iran.Scientific reports · 2024Article
- Phytosterols and the Digestive System: A Review Study from Insights into Their Potential Health Benefits and Safety.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Implication of Oxysterols and Phytosterols in Aging and Human Diseases.Advances in experimental medicine and biology · 2024Review
- The effects of a hydrolyzed protein diet on the plasma, fecal and urine metabolome in cats with chronic enteropathy.Scientific reports · 2023Article
- Phytosterols: From Preclinical Evidence to Potential Clinical Applications.Frontiers in pharmacology · 2020Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytosterols are known to reduce plasma cholesterol levels and thereby reduce cardiovascular risk. Studies conducted on human and animal models have demonstrated that these compounds have also anti-inflammatory effects. Recently, an experimental colitis model (dextran sulphate sodium-induced) has shown that pre-treatment with phytosterols decreases infiltration of inflammatory cells and accelerates mucosal healing. This study aims to understand the mechanism underlying the colitis by analysing the end-products of the metabolism in distal colon and liver excised from the same mice used in the previous work. In particular, an unsupervised gas chromatography-mass spectrometry (GC-MS) and NMR based metabolomics approach was employed to identify the metabolic pathways perturbed by the dextran sodium sulphate (DSS) insult (i.e. Krebs cycle, carbohydrate, amino acids, and nucleotide metabolism). Interestingly, phytosterols were able to restore the homeostatic equilibrium of the hepatic and colonic metabolome.
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