ArticleOrthodontics & craniofacial research2019
Novel application and validation of in vivo micro-CT to study bone modelling in 3D.
Article in Orthodontics & craniofacial research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Microstructural Analysis of the Human Scapula: Mandibular Bone Tissue Engineering Perspectives.Journal of functional biomaterials · 2024Article
- Human Bone Typing Using Quantitative Cone-Beam Computed Tomography.International dental journal · 2023Article
- Hallmarks of frailty and osteosarcopenia in prematurely aged PolgAJournal of cachexia, sarcopenia and muscle · 2020Article
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesThe aim is to highlight a novel three-dimensional (3D) imaging methodology using micro-CT scans to visualize and measure bone modelling in an animal model. In order to validate the new methodology, we compared the 3D imaging method to traditional two-dimensional (2D) histomorphometry to assess growth changes in the jaws of a rodent. SETTING AND SAMPLE POPULATION: Rodent animal models. MATERIAL AND
methodsEleven rats were obtained from a larger previously published study. Sixty undecalcified histological sections from the maxilla and corresponding high-resolution in vivo micro-CT reconstructions were obtained. Bone modelling changes on specific alveolar surfaces were measured using traditional histomorphometry. Measurements of bone growth were also obtained via 3D Slicer software from 3D micro-CT generated models from the same plane containing the histological images. Both qualitative and quantitative 3D methods were compared to traditional histological measurements. Quantitative agreement between methods was categorized as follows: poor (>150 μm), good (150-100 μm) and excellent (<100 μm).
resultsBoth qualitative (88.3%) and quantitative (86.7%) 3D measurements showed excellent agreement, when compared to histomorphometric measurements. Only 1.7% and 5% of the comparisons exhibited poor agreement (>150 μm) for qualitative and quantitative methods, respectively. DISCUSSION: The new 3D superimposition method compares very favourably with traditional histology. It is likely that in the future, such methods will be used in studies of bone adaptation.
conclusionThe 3D micro-CT qualitative and quantitative methods are reliable for measuring bone modelling changes and compare favourably to histology for the specific application described.
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Registered trials
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