Evidence map›Paper›PMID 31073814›Full record

ArticleInternational journal of clinical oncology2019

Clinical significance of prognostic nutritional index (PNI) in malignant melanoma.

Cem Mirili, Ali Yılmaz, Serkan Demirkan, Mehmet Bilici, Salim Basol Tekin

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical significance of prognostic nutrition index in hospitalized patients with COVID-19: Results from single-center experience with systematic review and meta-analysis.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2021
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  10. Prognostic utility of the CALLY index in metastatic melanoma: building a nomogram for Patients on Anti-PD-1 therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  16. Prognostic value of prognostic nutritional index in patients with nasopharyngeal carcinoma treated with endostar and concurrent chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cem MiriliDepartment of Medical Oncology, Ataturk University Faculty of Medicine, 25050, Yakutiye, Erzurum, Turkey. cemirili@gmail.com.ORCID http://orcid.org/0000-0002-5986-5493
Ali YılmazDepartment of Medical Oncology, Ataturk University Faculty of Medicine, 25050, Yakutiye, Erzurum, Turkey.
Serkan DemirkanDepartment of Dermatology, Katip Çelebi University Ataturk Education and Research Hospital, İzmir, Turkey.
Mehmet BiliciDepartment of Medical Oncology, Ataturk University Faculty of Medicine, 25050, Yakutiye, Erzurum, Turkey.
Salim Basol TekinDepartment of Medical Oncology, Ataturk University Faculty of Medicine, 25050, Yakutiye, Erzurum, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNutrition and inflammation play a crucial role in the development of cancer. The prognostic value of the prognostic nutritional index (PNI) has been confirmed in some types of human cancers. However, few studies are available indicating its prognostic power in patients with malignant melanoma (MM). Thus, we aimed to identify baseline peripheral blood biomarkers to predict the outcome of MM patients MATERIAL AND

methodsData of 101 patients with MM were evaluated retrospectively. Associations between clinical and histopathological parameters with overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier curves and compared by the log-rank test. The optimal cutoff values were determined by a receiver operating characteristic (ROC) curve analysis. Neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and PNI were grouped based on a cutoff points 2.18, 547.1, and 40.1, respectively. Univariate and multivariate analyses were used to assess their prognostic values for overall survival (OS).

resultsLower NLR ( < 2.18), SII ( < 547.1) and higher PNI ( ≥ 40.1) were linked with a longer PFS and OS in patients with MM, as reflected in the Kaplan-Meier analyses. In univariate analysis, TNM stage, Breslow thickness, Clark stage, ulceration, Ki67 status, LDH, NLR, SII, and PNI were significantly associated with OS. Multivariate analysis identified TNM stage, ulceration, LDH and PNI as an independent predictor of OS in patients with MM.

conclusionPNI can be regarded as a novel independent prognostic factor for predicting OS in MM.

Indexed as

Nutritional StatusNutrition AssessmentAdultAgedAged, 80 and overBiomarkersFemaleHumansInflammationLymphocytesMaleMelanomaMiddle AgedNeutrophilsPrognosisRetrospective StudiesBiomarkersMalignant melanomaNeutrophil–lymphocyte ratioPrognostic nutritional indexSystemic immune-inflammation index

Identifiers

PMID31073814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.