Evidence map›Paper›PMID 31073768›Full record

ArticleEJNMMI research2019

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation.

S K Vainio, A M Dickens, J Tuisku, O Eskola, O Solin, E Löyttyniemi, D C Anthony, J O Rinne, L Airas, M Haaparanta-Solin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

S K VainioTurku PET Centre, Preclinical PET Imaging, University of Turku, Tykistökatu 6 A, 20520, Turku, Finland. susanne.k.vainio@utu.fi.ORCID http://orcid.org/0000-0001-5171-7480
A M DickensTurku Centre for Biotechnology, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-3178-8449
J TuiskuTurku PET Centre, Clinical Neurology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0003-0965-9365
O EskolaTurku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-9874-5662
O SolinTurku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0003-1026-4029
E LöyttyniemiDepartment of Biostatistics, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-7278-6511
D C AnthonyDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1380-6655
J O RinneTurku PET Centre, Clinical Neurology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0001-6369-0764
L AirasTurku PET Centre, Clinical Neurology, Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0002-9751-5881
M Haaparanta-SolinTurku PET Centre, Preclinical PET Imaging, University of Turku, Tykistökatu 6 A, 20520, Turku, Finland.ORCID http://orcid.org/0000-0002-3602-4587
University of Turku · FITurku University Hospital · FIÅbo Akademi University · FIUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protein (TSPO) binding radioligand [

resultsAfter a 2-week treatment period on day 44, there was a declining trend (p = 0.067) in [

conclusionsThese results demonstrated that cessation of anti-VLA-4 mAb treatment for 4 days caused a transient rebound increase in neuroinflammation. This highlights the usefulness of serial TSPO imaging in the fDTH-EAE model to better understand the rebound phenomenon.

Indexed as

[18F]GE-180Anti-VLA-4EAEMultiple sclerosisPositron emission tomographyTSPO

Identifiers

PMID31073768
PMCPMC6509289
OpenAlexW2944212157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.