ArticleCalcified tissue international2019
Long Noncoding RNA Analyses for Osteoporosis Risk in Caucasian Women.
Article in Calcified tissue international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Cross-Tissue Multiomics Analysis Reveals the Protective Role of TGFBR3 in Postmenopausal Osteoporosis.International journal of genomics · 2026Article
- Development and experimental validation of an energy metabolism-related gene signature for diagnosing of osteoporosis.Scientific reports · 2024Article
- Identification of potential pathogenic genes related to osteoporosis and osteoarthritis.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
- Identification of neutrophil extracellular traps and crosstalk genes linking inflammatory bowel disease and osteoporosis by integrated bioinformatics analysis and machine learning.Scientific reports · 2023Article
- Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers.Bioengineered · 2021Article
- The potential role of lncRNAs in osteoporosis.Journal of bone and mineral metabolism · 2021Review
- The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis.International journal of molecular sciences · 2020Review
- LncRNA RP1-85F18.6 affects osteoblast cells by regulating the cell cycle.Open life sciences · 2020Article
- Identification and Analysis of Genes Underlying Bone Mineral Density by Integrating Microarray Data of Osteoporosis.Frontiers in cell and developmental biology · 2020Article
- Editorial: Old Bones.The journal of nutrition, health & aging · 2020Article
- The regulatory roles of long noncoding RNAs in osteoporosis.American journal of translational research · 2020Review
- Integrative Analyses of Genes Associated With Osteoporosis in CD16+ Monocyte.Frontiers in endocrinology · 2020Article
- Integrative Analysis of Genomics and Transcriptome Data to Identify Regulation Networks in Female Osteoporosis.Frontiers in genetics · 2020Article
- Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.BioMed research international · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionOsteoporosis is a prevalent bone metabolic disease characterized by bone fragility. As a key pathophysiological mechanism, the disease is caused by excessive bone resorption (by osteoclasts) over bone formation (by osteoblasts). Peripheral blood monocytes (PBMs) is a major systemic cell model for bone metabolism by serving as progenitors of osteoclasts and producing cytokines important for osteoclastogenesis. Protein-coding genes for osteoporosis have been widely studied by mRNA analyses of PBMs in high versus low hip bone mineral density (BMD) subjects. However, long noncoding RNAs (lncRNAs), which account for a large proportion of human transcriptome, have seldom been studied.
methodsIn this study, microarray analyses of monocytes were performed using Affymetrix exon 1.0 ST arrays in 73 Caucasian females (age: 47-56). LncRNA profile was generated by re-annotating exon array for lncRNAs detection, which yielded 12,007 lncRNAs mapped to the human genome.
results575 lncRNAs were differentially expressed between the two groups. In the high BMD subjects, 309 lncRNAs were upregulated and 266 lncRNAs were downregulated (nominally significant, raw p-value < 0.05). To investigate the relationship between mRNAs and lncRNAs, we used two approaches to predict the target genes of lncRNAs and found that 26 candidate lncRNAs might regulate mRNA expression. The majority of these lncRNAs were further validated to be potentially correlated with BMD by GWAS analysis.
conclusionOverall, our findings for the first time reported the lncRNAs profiles for osteoporosis and suggested the potential regulatory mechanism of lncRNAs on protein-coding genes in bone metabolism.
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