ReviewDementia & neuropsychologia
How stress mediators can cumulatively contribute to Alzheimer's disease An allostatic load approach.
Review in Dementia & neuropsychologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social class and the risk of dementia: A systematic review and meta-analysis of the prospective longitudinal studies.Scandinavian journal of public health · 2023Pooled it
- Dyadic Comparison of Pain and Stress in Alzheimer's Disease and Caregivers.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- Does Allostatic Load in 50-89-Year-Olds Predict the Development of Frailty? Evidence From a National Longitudinal Study Over 12 Years.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- Allostatic load, a measure of cumulative physiological stress, impairs brain structure but notFrontiers in aging neuroscience · 2025Article
- Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Astroglial Dysfunctions in Mood Disorders and Rodent Stress Models: Consequences on Behavior and Potential as Treatment Target.International journal of molecular sciences · 2024Review
- The Role of Steroidomics in the Diagnosis of Alzheimer's Disease and Type 2 Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients.Brain, behavior, & immunity - health · 2023Article
- Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2023Article
- The increased cortisol levels with preserved rhythmicity in aging and its relationship with dementia and metabolic syndrome.Aging clinical and experimental research · 2022Article
- Voice biomarkers as indicators of cognitive changes in middle and later adulthood.Neurobiology of aging · 2022Article
- Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.Mechanisms of ageing and development · 2021Article
- The Concept of Advanced Multi-Sensor Monitoring of Human Stress.Sensors (Basel, Switzerland) · 2021Review
- Advances in Understanding the Causes and Consequences of Health Disparities in Aging Minorities.Current epidemiology reports · 2020Article
- The Alzheimer's Disease Exposome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Physical activity attenuates the association between allostatic load and early Alzheimer's disease-related biomarkers in older adults.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allostatic load is defined as the frequent activation of the neuroendocrine, immunological, metabolic and cardiovascular systems, which makes individuals more susceptible to stress-related health problems. According to this model, physiological dysregulations start to emerge decades before diseases manifest. Consequently, stress research has shifted its attention to anticipating the degree of this dysregulation to better understand the impact of stress hormones and other biomarkers on disease progression. In view of the growing number of studies that demonstrate the influence of modifiable risk factors on cognitive decline, in addition to the effects of chronic stress mediators, the objective of the present review was to present an overview of the development of cognitive changes based on studies on stress and its mediators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.