Evidence map›Paper›PMID 31073336›Full record

ArticleMobile DNA2019

Insertion of a chimeric retrotransposon sequence in mouse

Zhuqing Wang, Hayden McSwiggin, Simon J Newkirk, Yue Wang, Daniel Oliver, Chong Tang, Sandy Lee, Shawn Wang, Shuiqiao Yuan, Huili Zheng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mobile DNA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Ablation of theFrontiers in endocrinology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Zhuqing Wang1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Hayden McSwiggin1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Simon J Newkirk3Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007 USA.
Yue Wang1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Daniel Oliver1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Chong Tang1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Sandy Lee1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Shawn Wang1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Shuiqiao Yuan1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Huili Zheng1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
Ping Ye2Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108 USA.
Wenfeng An3Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007 USA.
Wei Yan1Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Room 207B 1664 North Virginia Street MS/0575, Reno, NV 89557 USA.
University of Nevada, Reno · USSouth Dakota State University · USAvera McKennan Hospital & University Health Center · US

Funding

Training CoreP50GM107632 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOEKE, JEF D · 2013 to 2017
$10.0M
Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Messenger RNA Fate Control in SpermatogenesisR01HD085506 · NICHD · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2015 to 2019
$1.5M
Investigating an Etiological Role of LINE-1 Retrotransposition in Birth DefectsR21HD080143 · NICHD · SOUTH DAKOTA STATE UNIVERSITY · PI AN, WENFENG · 2015 to 2016
$400k
Are sperm-borne small RNAs important?R21HD071736 · NICHD · UNIVERSITY OF NEVADA RENO · PI YAN, WEI · 2012 to 2013
$380k
NICHD NIH HHS R01 HD085506NICHD NIH HHS R21 HD071736NICHD NIH HHS R21 HD080143NIGMS NIH HHS P30 GM110767NIGMS NIH HHS P50 GM107632
6 · The paper itself

Abstract

backgroundTransposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns. However, the effects of retrotransposition on the host genes remain incompletely known.

resultsWe report here that insertion of a chimeric L1 (cL1), but not IAP solo LTR, into intron 6 of

conclusionsThe mechanism for

Indexed as

Alternative splicingCRISPR/Cas9DNA methylationEpigenetic inheritanceHistone modificationIAPLINE-1MaLRRetrotransposon

Identifiers

PMID31073336
PMCPMC6500023
OpenAlexW2947031495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.