ReviewJournal of biological engineering2019
Genetic circuits to engineer tissues with alternative functions.
Review in Journal of biological engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Tissue engineering driven regeneration in oral squamous cell carcinoma: from biomaterials to precision gene editing.Journal of the Egyptian National Cancer Institute · 2026Review
- Advancing cell therapies with artificial intelligence and synthetic biology.Current opinion in biomedical engineering · 2025Article
- Programming megakaryocytes to produce engineered platelets for delivering non-native proteins.Communications biology · 2025Article
- Machine Learning and Deep Learning in Synthetic Biology: Key Architectures, Applications, and Challenges.ACS omega · 2024Review
- Programmable mammalian translational modulators by CRISPR-associated proteins.Nature communications · 2023Article
- A quantitative evaluation of topological motifs and their coupling in gene circuit state distributions.iScience · 2023Article
- Synthetic Biology Meets Machine Learning.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns.PLoS computational biology · 2022Article
- From DNA-protein interactions to the genetic circuit design using CRISPR-dCas systems.Frontiers in molecular biosciences · 2022Review
- Design and development of engineered receptors for cell and tissue engineering.Current opinion in systems biology · 2021Article
- Enhanced regulation of prokaryotic gene expression by a eukaryotic transcriptional activator.Nature communications · 2021Article
- High-throughput enrichment and isolation of megakaryocyte progenitor cells from the mouse bone marrow.Scientific reports · 2021Article
- Biological Cells as Therapeutic Delivery Vehicles.Trends in pharmacological sciences · 2021Review
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Novel Tunable Spatio-Temporal Patterns From a Simple Genetic Oscillator Circuit.Frontiers in bioengineering and biotechnology · 2020Article
- Rosa26 docking sites for investigating genetic circuit silencing in stem cells.Synthetic biology (Oxford, England) · 2020Article
- Bioengineering tools for the production of pharmaceuticals: current perspective and future outlook.Bioengineered · 2019Review
- Review
- Synthetic biology for improving cell fate decisions and tissue engineering outcomes.Emerging topics in life sciences · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Persistent and complex problems arising with respect to human physiology and pathology have led to intense investigation into therapies and tools that permit more targeted outcomes and biomimetic responses to pathological conditions. A primary goal in mammalian synthetic biology is to build genetic circuits that exert fine control over cell behavior for next-generation biomedical applications. In pursuit of this, synthetic biologists have engineered cells endowed with genetic circuits with sensor that are capable of reacting to a variety of stimuli and responding with targeted behavior. Here, we highlight how synthetic biology approaches are being used to program cells with novel functions for therapeutic applications, and how they can be used in stem cells to improve differentiation outcomes. These approaches open the possibilities for engineering synthetic tissues for employing personalized medicine and to develop next-generation biomedical therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.