Evidence map›Paper›PMID 31073325›Full record

ArticleInfectious agents and cancer2019

The burden of cancers associated with HIV in the South African public health sector, 2004-2014: a record linkage study.

Tafadzwa Dhokotera, Julia Bohlius, Adrian Spoerri, Matthias Egger, Jabulani Ncayiyana, Victor Olago, Elvira Singh, Mazvita Sengayi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cancer in People with HIV.Infectious disease clinics of North America · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tafadzwa Dhokotera1National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.ORCID 0000-0002-4353-0787
Julia Bohlius3Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Adrian Spoerri3Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Matthias Egger3Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Jabulani Ncayiyana2Division of Epidemiology and Biostatistics, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Victor Olago1National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
Elvira Singh1National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
Mazvita Sengayi1National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
National Health Laboratory Service · ZAUniversity of Bern · CHUniversity of Cape Town · ZA

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
NIAID NIH HHS U01 AI069924
6 · The paper itself

Abstract

introductionThe impact of South Africa's high human immunodeficiency virus (HIV) burden on cancer risk is not fully understood, particularly in the context of antiretroviral treatment (ART) availability. We examined national cancer trends and excess cancer risk in people living with HIV (PLHIV) compared to those who are HIV-negative.

methodsWe used probabilistic record linkage to match cancer records provided by the National Cancer Registry to HIV data provided by the National Health Laboratory Service (NHLS). We also used text search of specific HIV terms from the clinical section of pathology reports to determine HIV status of cancer patients. We used logistic and Joinpoint regression models to evaluate the risk and trends in cancers in PLHIV compared to HIV-negative patients from 2004 to 2014. In sensitivity analysis, we used inverse probability weighting (IPW) to correct for possible selection bias.

resultsA total of 329,208 cancer cases from public sector laboratories were reported to the NCR from 2004 to 2014 with the HIV status known for 95,279 (28.9%) cancer cases. About 50% of all the female cancer cases (

conclusionThere is need for improved awareness and screening of conjunctival cancer and HPV-associated cancers at HIV care centres. Further research and discussion is warranted on inclusive HPV vaccination in PLHIV.

Indexed as

Antiretroviral eraCancer riskEpidemiologyHIV and cancerSouth Africa

Identifiers

PMID31073325
PMCPMC6500038
OpenAlexW2944332154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.