Evidence map›Paper›PMID 31073226›Full record

ArticleScientific reports2019

De novo aggregation of Alzheimer's Aβ25-35 peptides in a lipid bilayer.

Amy K Smith, Dmitri K Klimov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Saponin components inFrontiers in pharmacology · 2024
    Review
  3. Article
  4. Article
  5. Polycationic peptide RBiochemistry and biophysics reports · 2022
    Article
  6. Article
  7. Review
  8. Identification ofCell reports. Medicine · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy K SmithSchool of Systems Biology, George Mason University, Manassas, VA, 20110, USA.
Dmitri K KlimovSchool of Systems Biology, George Mason University, Manassas, VA, 20110, USA. dklimov@gmu.edu.ORCID http://orcid.org/0000-0002-2893-867X
George Mason University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A potential mechanism of cytotoxicity attributed to Alzheimer's Aβ peptides postulates that their aggregation disrupts membrane structure causing uncontrollable permeation of Ca

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesDimerizationDimyristoylphosphatidylcholineHumansLipid BilayersMolecular Dynamics SimulationPeptide FragmentsProtein AggregatesProtein BindingThermodynamicsAmyloid beta-Peptidesamyloid beta-protein (25-35)DimyristoylphosphatidylcholineLipid BilayersPeptide FragmentsProtein Aggregates

Identifiers

PMID31073226
PMCPMC6509337
OpenAlexW2943949666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.