Evidence map›Paper›PMID 31073167›Full record

ArticleScientific reports2019

Pharmacological Mobilization and Recruitment of Stem Cells in Rats Stops Abdominal Adhesions After Laparotomy.

Kenichi Iwasaki, Ali Reza Ahmadi, Le Qi, Melissa Chen, Wei Wang, Kenji Katsumata, Akihiko Tsuchida, James Burdick, Andrew M Cameron, Zhaoli Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Induction of Skin Allograft Chimerism by Pharmacological Mobilization of Endogenous Bone Marrow-Derived Stem Cells.Journal of burn care & research : official publication of the American Burn Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kenichi IwasakiDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ali Reza AhmadiDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Le QiDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Melissa ChenDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wei WangDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kenji KatsumataDepartment of Gastrointestinal Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Akihiko TsuchidaDepartment of Gastrointestinal Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
James BurdickDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew M CameronDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhaoli SunDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. zsun2@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adhesions are a very common complication in the abdominal surgery. Animal studies and human trials have evaluated strategies designed to reduce and prevent postsurgical adhesions but few have an evidence base that justifies routine use. A strategy to prevent adhesions effectively remains an urgent need. We studied a reproducible model of intra-peritoneal adhesion formation in rats using laparotomy with several peritoneal sutures to produce the adhesions. Here we show that entraining endogenous stem cells into injury sites using the combined effect of AMD3100 and low-dose FK-506 (AF) can reduce the adhesion score significantly and abolish peritoneal adhesions in 45% of animals in a rat model of severe postsurgical intra-abdominal adhesions, compared with saline controls. Searching for mechanisms, we found AF treatment dramatically increased SDF-1 expressing cells, HGF expressing Ym1+ M2 macrophages and CD133+ stem cells in the injury sites of peritoneal surface at day 5 post-operation. Our results demonstrate that medically induced recruitment of autologous stem cells using AF significantly reduced postsurgical intra-abdominal adhesions. These findings suggest a novel effective therapeutic approach to preventing adhesions in patients.

Indexed as

AbdomenAC133 AntigenAnimalsBenzylaminesCase-Control StudiesChemokine CXCL12CyclamsDisease Models, AnimalHepatocyte Growth FactorHeterocyclic CompoundsLaparotomyMacrophagesPeritoneumRatsRats, Inbred LewStem CellsAC133 AntigenBenzylaminesChemokine CXCL12Cxcl12 protein, mouseCyclamsHepatocyte Growth FactorHeterocyclic CompoundsHGF protein, mouseplerixaforTacrolimus

Identifiers

PMID31073167
PMCPMC6509124
OpenAlexW2944185962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.