ArticleScientific reports2019
Unpredictable Chronic Mild Stress Suppresses the Incorporation of New Neurons at the Caudal Pole of the Chicken Hippocampal Formation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Genome-Wide Association Analysis of Hippocampal Neuroplasticity as an Indicator of Stress Responsiveness in Laying Hens (Gallus gallus domesticus).Animal genetics · 2026Article
- The quantitative anatomy of the hippocampal formation in homing pigeons and other pigeon breeds: implications for spatial cognition.Brain structure & function · 2024Article
- The Effect of Rearing and Adult Environment on HPA Axis Responsivity and Plumage Condition in Laying Hens.Animals : an open access journal from MDPI · 2024Article
- Neuronal plasticity in hippocampal neurons due to chronic mild stress and after stress removal in postnatal chicks.Journal of anatomy · 2024Article
- Poor body condition is associated with lower hippocampal plasticity and higher gut methanogen abundance in adult laying hens from two housing systems.Scientific reports · 2022Article
- Perspective: Chicken Models for Studying the Ontogenetic Origin of Neuropsychiatric Disorders.Biomedicines · 2022Article
- Perspective: Gestational Tryptophan Fluctuation Altering Neuroembryogenesis and Psychosocial Development.Cells · 2022Article
- Article
- Telencephalic regulation of the HPA axis in birds.Neurobiology of stress · 2021Article
- Acute stress-induced neuronal plasticity in the corticoid complex of 15-day-old chick, Gallus domesticus.Journal of anatomy · 2021Article
- Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress.Animals : an open access journal from MDPI · 2021Article
- Artificial Light at Night Increases Recruitment of New Neurons and Differentially Affects Various Brain Regions in Female Zebra Finches.International journal of molecular sciences · 2020Article
- Smaller brains in laying hens: New insights into the influence of pure breeding and housing conditions on brain size and brain composition.Poultry science · 2020Article
- Keel bone fractures induce a depressive-like state in laying hens.Scientific reports · 2020Article
- Cell Proliferation in the Adult Chicken Hippocampus Correlates With Individual Differences in Time Spent in Outdoor Areas and Tonic Immobility.Frontiers in veterinary science · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In the mammalian brain, adult hippocampal neurogenesis (AHN) is suppressed by chronic stress, primarily at the ventral pole of the hippocampus. Based upon anatomy, we hypothesise that the caudal pole of the avian Hippocampal Formation (HF) presents a homologous subregion. We thus investigated whether AHN is preferentially suppressed in the caudal chicken HF by unpredictable chronic mild stress (UCMS). Adult hens were kept in control conditions or exposed to UCMS for 8 weeks. Hens experiencing UCMS had significantly fewer doublecortin-positive multipolar neurons (p < 0.001) and beaded axons (p = 0.021) at the caudal pole of the HF than controls. UCMS birds also had smaller spleens and lower baseline plasma corticosterone levels compared to controls. There were no differences in AHN at the rostral pole, nor were there differences in expression of genetic mediators of the HPA stress response in the pituitary or adrenal glands. Duration of tonic immobility and heterophil/lymphocyte (H/L) ratios were also not responsive to our UCMS treatment. These results support the hypothesised homology of the caudal pole of the avian HF to the ventral pole of the rodent hippocampus. Furthermore, quantifying neurogenesis in the caudal HF post-mortem may provide an objective, integrative measure of welfare in poultry, which may be more sensitive than current welfare measures.
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