ArticleThe European respiratory journal2019
Epigenome-wide association study of lung function level and its change.
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Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.American journal of respiratory and critical care medicine · 2022Pooled it
- Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.Clinical epigenetics · 2025Trial
- The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- Critical Biological Functions and Clinical Implications of Epigenetic-Related Candidate Biomarkers in Chronic Obstructive Pulmonary Disease: Integrated Machine Learning Screening and Basic Experimental Validation.International journal of chronic obstructive pulmonary disease · 2026Article
- Interactive effects of genotype with prenatal stress on DNA methylation at birth.Molecular psychiatry · 2025Article
- Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues.BMC genomics · 2025Article
- Role of Epigenetics in Chronic Lung Disease.Cells · 2025Review
- Development and validation of a predictive model for COPD: a multicenter study.Frontiers in medicine · 2025Article
- Effective-Component Compatibility of Bufei Yishen Formula (ECC-BYF) III Inhibits Mucus Hypersecretion by BEAS-2B Cells via miR-146a-5p-Mediated Regulation of the EGFR/MEK/ERK Pathway.International journal of chronic obstructive pulmonary disease · 2025Article
- DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise.Clinical epigenetics · 2024Article
- The association of cigarette smoking with DNA methylation and gene expression in human tissue samples.American journal of human genetics · 2024Article
- Blood DNA methylation signature of diet quality and association with cardiometabolic traits.European journal of preventive cardiology · 2024Article
- Epigenome-wide association studies of allergic disease and the environment.The Journal of allergy and clinical immunology · 2023Review
- Social-epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors.Cancer communications (London, England) · 2023Article
- Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.PLoS genetics · 2023Article
- Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort.Addiction biology · 2023Article
- Dynamics and consequences of nutrition-related microbial dysbiosis in early life: study protocol of the VITERBI GUT project.Frontiers in nutrition · 2023Article
- A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits.Nature communications · 2022Article
- Omics and Lung Function: A Need for Integration.American journal of respiratory and critical care medicine · 2022Article
- Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation.Respiratory research · 2022Article
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Authors and funding
39 authors at 17 institutions in 8 countries.
Medea ImbodenChronic Disease Epidemiology Unit, Dept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Matthias WielscherMRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Faisal I RezwanHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
André F S AmaralMRC-PHE Centre for Environment and Health, Imperial College London, London, UK.ORCID 0000-0002-0369-9449
Emmanuel SchaffnerChronic Disease Epidemiology Unit, Dept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Ayoung JeongChronic Disease Epidemiology Unit, Dept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Anna Beckmeyer-BorowkoChronic Disease Epidemiology Unit, Dept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.ORCID 0000-0003-1447-7419
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Claudia FlexederInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Melanie WaldenbergerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Su ChenDept of Mathematical Sciences, University of Memphis, Memphis, TN, USA.
Shadia Khan SunnyDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Wilfried J J KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Yu JiangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Gertraud ErhartDivision of Genetic Epidemiology, Dept of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Florian KronenbergDivision of Genetic Epidemiology, Dept of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Ryan ArathimosMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Gemma C SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Alexander John HendersonDept of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Yu FuInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Päivi PiiriläUnit of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Programs Unit, University of Helsinki, Helsinki, Finland.
Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Asa JohanssonDept of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Ulf GyllenstenDept of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Maaike de VriesUniversity of Groningen, University Medical Center Groningen, Dept of Epidemiology, Groningen, The Netherlands.ORCID 0000-0001-7210-8174
Diana A van der PlaatUniversity of Groningen, University Medical Center Groningen, Dept of Epidemiology, Groningen, The Netherlands.
Kim de JongUniversity of Groningen, University Medical Center Groningen, Dept of Epidemiology, Groningen, The Netherlands.
H Marike BoezenUniversity of Groningen, University Medical Center Groningen, Dept of Epidemiology, Groningen, The Netherlands.
Ian P HallDivision of Respiratory Medicine, University of Nottingham, Nottingham, UK.
Martin D TobinDept of Health Sciences, University of Leicester, Leicester, UK.
Marjo-Riitta JarvelinDept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-9998-0464
Deborah JarvisMRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Nicole M Probst-HenschChronic Disease Epidemiology Unit, Dept of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Swiss Tropical and Public Health Institute · CHHelmholtz Zentrum München · DEUniversity Medical Center Groningen · NLUniversity of Helsinki · FIUniversity of Memphis · USImperial College London · GBInnsbruck Medical University · ATUniversity of Bristol · GBUniversity of Southampton · GBUppsala University · SEAlzheimer Scotland · GBOulu University Hospital · FIUniversity Of Bristol Dental Hospital · GBUniversity of Edinburgh · GBUniversity of Leicester · GBUniversity of Nottingham · GBWestern General Hospital · GB
Funding
Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2MEffect of Prenatal Compounds on Adult Lung Function via Neonatal DNA MethylationR01HL132321 · NHLBI · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2016 to 2020
$3.2MMedical Research Council G0700704Medical Research Council G0901214Medical Research Council G1000861Medical Research Council MC_PC_12010Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1NHLBI NIH HHS R01 HL132321NIAID NIH HHS R01 AI121226Wellcome Trust 202849/Z/16/Z
Abstract
Previous reports link differential DNA methylation (DNAme) to environmental exposures that are associated with lung function. Direct evidence on lung function DNAme is, however, limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults.In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, 6-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2043). Associated DNAme markers (p<5×10
Indexed as
DNA MethylationEpigenesis, GeneticGenome-Wide Association StudyAdultAgedCpG IslandsFemaleForced Expiratory VolumeHumansLinear ModelsMaleMendelian Randomization AnalysisMiddle AgedReference ValuesSmokingSpirometry
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