Evidence map›Paper›PMID 31073070›Full record

ArticleHaematologica2020

CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient-derived strains.

Bianca Nowlan, Elizabeth D Williams, Michael R Doran, Jean-Pierre Levesque

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The CD70-CD27 axis in oncology: the new kids on the block.Journal of experimental & clinical cancer research : CR · 2022
    Review
  6. Maternal microchimerism and cell-mediated immune-modulation enhance engraftment following semi-allogenic intrauterine transplantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Bianca NowlanStem Cell Therapies Laboratory, School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Brisbane.
Elizabeth D WilliamsSchool of Biomedical Science, Faculty of Health, Institute of Health and Biomedical Innovation, QUT, Kelvin Grove, Queensland.
Michael R DoranStem Cell Therapies Laboratory, School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Brisbane jp.levesque@mater.uq.edu.au mike@mikedoranlab.com.
Jean-Pierre LevesqueMater Research Institute - The University of Queensland, Woolloongabba jp.levesque@mater.uq.edu.au mike@mikedoranlab.com.
Mater Research · AUProstate Cancer Research · GBQueensland University of Technology · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staining for CD27 and CD201 (endothelial protein C receptor) has been recently suggested as an alternative to stem cell antigen-1 (Sca1) to identify hematopoietic stem cells in inbred mouse strains with low or nil expression of SCA1. However, whether staining for CD27 and CD201 is compatible with low fms-like tyrosine kinase 3 (FLT3) expression and the "SLAM" code defined by CD48 and CD150 to identify mouse long-term reconstituting hematopoietic stem cells has not been established. We compared the C57BL/6 strain, which expresses a high level of SCA1 on hematopoietic stem cells to non-obese diabetic severe combined immune deficient NOD.CB17-

Indexed as

Diabetes Mellitusfms-Like Tyrosine Kinase 3AnimalsEndothelial Protein C ReceptorHematopoietic Stem CellsMiceMice, Inbred C57BLMice, Inbred NODReceptors, Cell SurfaceStaining and LabelingEndothelial Protein C Receptorfms-Like Tyrosine Kinase 3Receptors, Cell Surface

Identifiers

PMID31073070
PMCPMC6939540
OpenAlexW2944061541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.