ArticleScience (New York, N.Y.)2019
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92citing papers in PubMed
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Who cites it
92 citing papers in PubMed.
- Chronic Electroconvulsive Shock Disrupts Hippocampal Physiology and Impairs Associative Memory in Mice.Hippocampus · 2026Article
- Molecular pathways underlying amyloid precursor protein-mediated regulation of adult-born neurons.Neural regeneration research · 2026Article
- Sex-specific effects of maternal gestational diabetes mellitus on offspring neurodevelopment: persistent hippocampal neurogenesis deficits in female but not male offspring.Experimental & molecular medicine · 2026Article
- Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Subregional activity in the dentate gyrus is amplified during elevated cognitive demands.eLife · 2026Article
- Aperiodicity in Mouse CA1 and DG Power Spectra.eNeuro · 2026Article
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors.Cell stem cell · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Adult hippocampal neurogenesis: New avenues for treatment of brain disorders.Stem cell reports · 2025Review
- Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time.Nature neuroscience · 2025Article
- Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits.Cell research · 2025Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Article
- Optimal sparsity in autoencoder memory models of the hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Adult Hippocampal Neurogenesis as a Therapeutic Target in Fetal Alcohol Spectrum Disorder.Advances in experimental medicine and biology · 2025Review
- Effect of adult hippocampal neurogenesis on pattern separation and its applications.Cognitive neurodynamics · 2024Article
- Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony between the Hippocampus and Cortex.Aging and disease · 2024Article
- The integrated stress response promotes neural stem cell survival under conditions of mitochondrial dysfunction in neurodegeneration.Aging cell · 2024Article
- Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease.Progress in neurobiology · 2024Review
32 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Victor M LunaDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA. victor.luna@nyspi.columbia.edu rh95@cumc.columbia.edu.ORCID 0000-0002-6879-4308
Christoph Anacker *Division of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.
Nesha S Burghardt *Department of Psychology, Hunter College, The City University of New York, New York, NY 10021, USA.ORCID 0000-0002-5415-1141
Hameda KhandakerDepartment of Psychology, Hunter College, The City University of New York, New York, NY 10021, USA.
Valentine AndreuDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.
Amira MilletteDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.
Paige LearyDepartments of Child and Adolescent Psychiatry, Neuroscience and Physiology, and Psychiatry and the Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA.
Rebecca RavenelleDepartment of Psychology, Hunter College, The City University of New York, New York, NY 10021, USA.ORCID 0000-0001-9811-9760
Jessica C JimenezDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.ORCID 0000-0001-7878-1618
Alessia MastrodonatoDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.
Christine A DennyDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA.ORCID 0000-0002-6926-2020
Andre A FentonCenter for Neural Science, New York University, New York, NY 10003, USA.ORCID 0000-0002-5063-1156
Helen E ScharfmanDepartments of Child and Adolescent Psychiatry, Neuroscience and Physiology, and Psychiatry and the Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA.
Rene HenDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and the Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, USA. victor.luna@nyspi.columbia.edu rh95@cumc.columbia.edu.ORCID 0000-0002-7763-4162
Funding
Basic and Translational Research Center for Reducing Health DisparitiesG12MD007599 · NIMHD · HUNTER COLLEGE · PI ANGULO, JESUS A · 2012 to 2017
$14.6MCircuits underlying overgeneralizationR01MH068542 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Rene Hen · 2003 to 2026
$5.7MEffect of Major Depression and antidepressants on human neurogenesisR01MH083862 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA, HEN, RENE · 2009 to 2018
$5.4MCellular Mechanisms of Antidepressant ActionR37MH068542 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HEN, RENE · 2008 to 2017
$4.1MOptogenetic dissection of hippocampal circuitry underlying Alzheimers diseaseDP5OD017908 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DENNY, CHRISTINE ANN · 2013 to 2017
$2.0MDiverse Roles of Adult Dentate Gyrus NeurogenesisR01NS081203 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2013 to 2017
$1.8MHippocampal neurogenesis, pattern separation & age-related cognitive impairments.R01AG043688 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FENTON, ANDRE ANTONIO, HEN, RENE · 2013 to 2017
$1.6MIDENTIFYING CELLULAR AND MOLECULAR SUBSTRATES OF TREATMENT-RESISTANT DEPRESSION.R00MH108719 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANACKER, CHRISTOPH · 2019 to 2021
$889k2-photon microscope for in vivo functional imaging of neuronal circuitsS10OD018464 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MOORE, HOLLY MARIE · 2015 to 2015
$847kThe Impact of Increasing Neurogenesis on Cognitive Deficits Related to AgingK01AG054765 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LUNA, VICTOR · 2017 to 2021
$655kIdentifying cellular and molecular substrates of treatment-resistant depression.K99MH108719 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ANACKER, CHRISTOPH · 2016 to 2017
$256kHSRD VA CDP 13-003NIA NIH HHS K01 AG054765NIA NIH HHS R01 AG043688NIH HHS DP5 OD017908NIH HHS S10 OD018464NIMHD NIH HHS G12 MD007599NIMH NIH HHS K99 MH108719NIMH NIH HHS R00 MH108719NIMH NIH HHS R01 MH068542NIMH NIH HHS R01 MH083862NIMH NIH HHS R37 MH068542NINDS NIH HHS R01 NS081203
Abstract
Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through
Indexed as
AnimalsCells, CulturedDentate GyrusEntorhinal CortexEvoked PotentialsHippocampusHumansMiceMice, TransgenicNeuronsReceptors, N-Methyl-D-AspartateSynapsesReceptors, N-Methyl-D-Aspartate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.