Evidence map›Paper›PMID 31073062›Full record

ArticleScience (New York, N.Y.)2019

Particulate methane monooxygenase contains only mononuclear copper centers.

Matthew O Ross, Fraser MacMillan, Jingzhou Wang, Alex Nisthal, Thomas J Lawton, Barry D Olafson, Stephen L Mayo, Amy C Rosenzweig, Brian M Hoffman

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed.

  1. Article
  2. Multiple quantumScience advances · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Regulatory mechanisms of CHFrontiers in microbiology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Histidine-Copper Site Variability in UiO-66: Monitoring Synthetic Intricacy with EPR Spectroscopy.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew O RossDepartment of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.ORCID 0000-0003-2115-9806
Fraser MacMillanHenry Wellcome Unit for Biological Electron Paramagnetic Resonance Spectroscopy, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK.ORCID 0000-0002-2410-4790
Jingzhou WangDivision of Biology, California Institute of Technology, MC 114-96, 1200 East California Boulevard, Pasadena, CA 91125, USA.ORCID 0000-0002-2850-330X
Alex NisthalDivision of Biology, California Institute of Technology, MC 114-96, 1200 East California Boulevard, Pasadena, CA 91125, USA.ORCID 0000-0001-5837-9453
Thomas J LawtonDepartment of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.
Barry D OlafsonProtabit, 1010 E. Union Street, Suite 110, Pasadena, CA 91106, USA.ORCID 0000-0002-8562-2583
Stephen L MayoDivision of Biology, California Institute of Technology, MC 114-96, 1200 East California Boulevard, Pasadena, CA 91125, USA.ORCID 0000-0002-9785-5018
Amy C RosenzweigDepartment of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA. amyr@northwestern.edu bmh@northwestern.edu.ORCID 0000-0001-8472-4134
Brian M HoffmanDepartment of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA. amyr@northwestern.edu bmh@northwestern.edu.ORCID 0000-0002-3100-0746

Funding

Metalloenzymes and metal homeostasisR35GM118035 · NIGMS · NORTHWESTERN UNIVERSITY · PI AMY C. ROSENZWEIG · 2016 to 2026
$7.1M
Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
NIGMS NIH HHS R01 GM111097NIGMS NIH HHS R35 GM118035NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

Bacteria that oxidize methane to methanol are central to mitigating emissions of methane, a potent greenhouse gas. The nature of the copper active site in the primary metabolic enzyme of these bacteria, particulate methane monooxygenase (pMMO), has been controversial owing to seemingly contradictory biochemical, spectroscopic, and crystallographic results. We present biochemical and electron paramagnetic resonance spectroscopic characterization most consistent with two monocopper sites within pMMO: one in the soluble PmoB subunit at the previously assigned active site (Cu

Indexed as

Catalytic DomainCopperCrystallography, X-RayElectron Spin Resonance SpectroscopyMethaneMethanolMethylococcus capsulatusOxidation-ReductionOxygenasesProtein ConformationCopperMethanemethane monooxygenaseMethanolOxygenases

Identifiers

PMID31073062
PMCPMC6664434

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.