Evidence map›Paper›PMID 31073032›Full record

ArticleThe Journal of biological chemistry2019

A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of

Sylvia C Hewitt, Sydney L Lierz, Marleny Garcia, Katherine J Hamilton, Artiom Gruzdev, Sara A Grimm, John P Lydon, Francesco J Demayo, Kenneth S Korach

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Chromatin architectural factor CTCF is essential for progesterone-dependent uterine maturation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Cell-type specific analysis of physiological action of estrogen in mouse oviducts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  14. Article
  15. Insulin signaling is an essential regulator of endometrial proliferation and implantation in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  16. Article
  17. Article
  18. Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation.Trends in endocrinology and metabolism: TEM · 2020
    Review
  19. Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk.International journal of molecular sciences · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sylvia C HewittFrom the Receptor Biology Group, Sylvia.hewitt@nih.gov.ORCID 0000-0001-7713-0805
Sydney L LierzFrom the Receptor Biology Group.
Marleny GarciaFrom the Receptor Biology Group.
Katherine J HamiltonFrom the Receptor Biology Group.
Artiom GruzdevKnockout Mouse Core Laboratory, and.
Sara A Grimmthe Integrative Bioinformatics Support Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 and.
John P Lydonthe Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030.
Francesco J DemayoPregnancy & Female Reproduction Group, Reproductive and Developmental Biology Laboratory and.
Kenneth S KorachFrom the Receptor Biology Group.
Research Triangle Park Foundation · USBaylor College of Medicine · USNational Institutes of Health · USTriangle · US

Funding

Chemical Receptor Interactions In Reproduction And Hormonal ToxicityZIAES070065 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KORACH, KENNETH S · 2009 to 2019
$29.6M
NIEHS Knock Out Mouse Core (KOMC) Annual ReportZICES102425 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RAY, MANAS · 2010 to 2025
$20.1M
Intramural NIH HHS ZIA ES070065
6 · The paper itself

Abstract

Insulin-like growth factor 1 (IGF1) is primarily synthesized in and secreted from the liver; however, estrogen (E2), through E2 receptor α (ERα), increases uterine

Indexed as

Enhancer Elements, GeneticAnimalsEstrogen Receptor alphaEstrogensFemaleGene Expression RegulationInsulin-Like Growth Factor IMiceMice, KnockoutTranscription, GeneticUterusEstrogen Receptor alphaEstrogensinsulin-like growth factor-1, mouseInsulin-Like Growth Factor Ichromatin immunoprecipitation (ChiP)chromatin structureestrogen receptorhormone receptorinsulin-like growth factor (IGF)mousenuclear receptorreproductiontranscription enhanceruterus

Identifiers

PMID31073032
PMCPMC6597841
OpenAlexW2944728655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.