ArticleThe Journal of biological chemistry2019
The selective estrogen receptor modulator raloxifene mitigates the effect of all-
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In one paragraph
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Physiotherapy training and education prior to elective Caesarean section and its impact on post-natal quality of life: a secondary analysis of a randomized controlled trial.BMC research notes · 2023Trial
- Toremifene-induced bilateral macular crystalline deposits with cystic cavitation: a case report.Frontiers in medicine · 2026Article
- Stereochemical Reassignment by Total Synthesis of an Ocular Pyridinium Bisretinoid of Retinal Pigment Epithelium Lipofuscin:Organic letters · 2025Article
- A Hypothesized Therapeutic Role of (Z)-Endoxifen in Duchenne Muscular Dystrophy (DMD).Degenerative neurological and neuromuscular disease · 2025Article
- Activation of GSDME by all-International journal of biological sciences · 2025Article
- Light as a Mediator of Acute and Chronic Retina Degeneration.Advances in experimental medicine and biology · 2025Review
- Crocin Protects the 661W Murine Photoreceptor Cell Line against the Toxic Effects of All-International journal of molecular sciences · 2024Article
- Tamoxifen protects photoreceptors in the sodium iodate model.Experimental eye research · 2024Article
- Cell-cell interaction in the pathogenesis of inherited retinal diseases.Frontiers in cell and developmental biology · 2024Review
- Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors.Neurotoxicity research · 2023Article
- Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal.International journal of ophthalmology · 2023Article
- Article
- All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion.Investigative ophthalmology & visual science · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Tamar GetterFrom the Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, California 92697, tgetter@uci.edu.
Susie SuhFrom the Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, California 92697.
Thanh Hoangthe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
James T Handathe Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Zhiqian DongPolgenix Inc., Irvine, California 92617.
Xiuli MaPolgenix Inc., Irvine, California 92617.
Yuanyuan Chenthe Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and.
Seth Blackshawthe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.ORCID 0000-0002-1338-8476
Krzysztof PalczewskiFrom the Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, California 92697, kpalczew@uci.edu.ORCID 0000-0002-0788-545X
Johns Hopkins University · USUniversity of California, Irvine · USPolgenix (United States) · USUniversity of Pittsburgh · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MSTRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0MNovel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1MUse of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9MTranscriptional regulation of retinal cell differentiation and functionR01EY020560 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2011 to 2021
$4.4MNRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9MOxidative stress and innate immunity impair the visual cycleR01EY027691 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2017 to 2021
$2.7MCole Eye Institute Vision Science Training ProgramT32EY024236 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2015 to 2025
$1.0MDrug discovery and mechanistic study of P23H rhodopsin associated retinitis pigmentosaR00EY024992 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, YUANYUAN · 2017 to 2019
$711kDrug discovery and mechanistic study of P23H rhodopsin associated retinitis pigmentosaK99EY024992 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, YUANYUAN · 2015 to 2016
$194kCRISPR/Cas9-Mediated Correction of Abca4 Mutations in a Stargardt Mouse ModelF30EY029136 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUH, SUSIE · 2019 to 2021
$152kNCATS NIH HHS TL1 TR002549NEI NIH HHS F30 EY029136NEI NIH HHS K99 EY024992NEI NIH HHS R00 EY024992NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY020560NEI NIH HHS R01 EY027691NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283NEI NIH HHS T32 EY024236NIGMS NIH HHS T32 GM007250
Abstract
The retinoid cycle is a metabolic process in the vertebrate retina that continuously regenerates 11-
Indexed as
Alcohol OxidoreductasesAnimalsATP-Binding Cassette TransportersFemaleMaleMiceMice, KnockoutPhotoreceptor Cells, VertebrateProtective AgentsRaloxifene HydrochlorideRetinal DegenerationRetinaldehydeRetinal Pigment EpitheliumSelective Estrogen Receptor ModulatorsAbca4 protein, mouseAlcohol OxidoreductasesATP-Binding Cassette TransportersHSD17B6 protein, mouseProtective AgentsRaloxifene HydrochlorideRetinaldehydeSelective Estrogen Receptor Modulatorsall-trans-retinal (atRAL)blindnesscell deathcytotoxicityestrogen receptor (ER)high-throughput screen (HTS)photoreceptor degenerationretinaretinal degenerationrhodopsinselective estrogen receptor modulator (SERM)visionvitamin A
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.