Evidence map›Paper›PMID 31073026›Full record

ArticleThe Journal of biological chemistry2019

DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast.

Pengli Bu, Shreya Nagar, Madhura Bhagwat, Pritpal Kaur, Ankita Shah, Joey Zeng, Ivana Vancurova, Ales Vancura

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Review
  9. When Phosphatases Go Mad: The Molecular Basis for Toxicity of Yeast Ppz1.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pengli BuFrom the Departments of Biological Sciences and.
Shreya NagarFrom the Departments of Biological Sciences and.
Madhura BhagwatFrom the Departments of Biological Sciences and.
Pritpal KaurFrom the Departments of Biological Sciences and.
Ankita ShahPharmaceutical Sciences, St. John's University, Queens, New York 11439.
Joey ZengFrom the Departments of Biological Sciences and.
Ivana VancurovaFrom the Departments of Biological Sciences and.
Ales VancuraFrom the Departments of Biological Sciences and vancuraa@stjohns.edu.
Queens College, CUNY · USSt. John's University · US

Funding

Transcriptional Regulation and MetabolismR15GM120710 · NIGMS · ST. JOHN'S UNIVERSITY · PI VANCURA, ALES · 2016 to 2016
$495k
NIGMS NIH HHS R15 GM120710
6 · The paper itself

Abstract

The DNA damage response (DDR) is an evolutionarily conserved process essential for cell survival. Previously, we found that decreased histone expression induces mitochondrial respiration, raising the question whether the DDR also stimulates respiration. Here, using oxygen consumption and ATP assays, RT-qPCR and ChIP-qPCR methods, and dNTP analyses, we show that DDR activation in the budding yeast

Indexed as

DNA DamageOxidative PhosphorylationOxygen ConsumptionAdenosine TriphosphateCell SurvivalChromatin Assembly and DisassemblyGene Expression Regulation, FungalHistonesMitochondriaNucleotidesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdenosine TriphosphateHistonesNucleotidesSaccharomyces cerevisiae ProteinsATPcell stresschromatinDNA damage responsedNTPenergy metabolismhistoneoxidative phosphorylation (OXPHOS)respirationtricarboxylic acid cycle (TCA cycle) (Krebs cycle)

Identifiers

PMID31073026
PMCPMC6597840
OpenAlexW2944084170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.