Evidence map›Paper›PMID 31072879›Full record

ArticleDisease models & mechanisms2019

Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity.

Alessandro A Bailetti, Lenny J Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A Bach

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Epigenetic Regulation in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  3. Notch Signaling in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Epigenetic regulation of post-embryonic development.Current opinion in insect science · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alessandro A BailettiDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-7551-4813
Lenny J Negrón-PiñeiroDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Vishal DhruvaDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Sneh HarshDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Sean LuDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Aisha BosulaDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Erika A BachDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA erika.bach@nyu.edu.ORCID 0000-0002-5997-4489
New York University · US

Funding

Eludicating the Molecular Mechanisms That Regulate Stem Cell Numbers in VivoR01GM085075 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2009 to 2023
$4.3M
NIGMS NIH HHS R01 GM085075
6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in

Indexed as

Signal TransductionAnimalsCarcinogenesisCell DifferentiationChromosomal Proteins, Non-HistoneDrosophila melanogasterDrosophila ProteinsHematologic NeoplasmsHematopoiesisHeterozygoteHistone AcetyltransferasesJanus KinasesMelanomaModels, BiologicalPhenotypeSTAT Transcription FactorsChromosomal Proteins, Non-HistoneDrosophila ProteinsE(Pc) protein, DrosophilaHistone Acetyltransferaseshop protein, DrosophilaJanus KinasesSTAT Transcription FactorsTip60 protein, DrosophilaTranscription FactorsDrosophilaE(Pc)JAK/STATLysine acetyltransferasesMelanotic tumorsMyeloproliferative neoplasmsTip60Tumor suppressor

Identifiers

PMID31072879
PMCPMC6550037
OpenAlexW2943942997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.