Observational studyBMJ open2019
Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing.
Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies.Journal of sport and health science · 2021Pooled it
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Determining the Protective Role of Grip Strength in Cardiovascular and Cerebrovascular Disease Risk Among Middle-Aged and Older Women in South Korea.Journal of epidemiology and global health · 2026Article
- Handgrip strength across clinical conditions and health-related outcomes in older adults: a scoping review.Frontiers in aging · 2026Review
- Trajectories of grip strength decline and risk of new-onset cardiovascular disease: evidence from the HRS and ELSA cohorts.Frontiers in public health · 2026Article
- A grip strength prediction tool for older adults based on logistic regression: construction, validation, and clinical application value.Scientific reports · 2025Article
- Article
- Could self-reported physical performance help predict individuals at the highest risk of mortality and hospital admission events in clinical practice? Findings from the Hertfordshire Cohort Study.Primary health care research & development · 2024Article
- The association of appendicular lean mass and grip strength with low-density lipoprotein, very low-density lipoprotein, and high-density lipoprotein particle diameter: a Mendelian randomization study of the UK Biobank cohort.European heart journal open · 2024Article
- Effects of measurement protocols and repetitions on handgrip strength weakness and asymmetry in patients with cancer.Journal of cachexia, sarcopenia and muscle · 2024Article
- Article
- A Reciprocal Relationship between Formal and Informal Social Engagement and Handgrip Strength of Older Adults in South Korea.Gerontology · 2024Article
- Follow-Up of Eight-Weeks Detraining Period after Exercise Program on Health Profiles of Older Women.Healthcare (Basel, Switzerland) · 2023Article
- Handgrip strength is associated with mortality in community-dwelling older adults: the Yilan cohort study, Taiwan.BMC public health · 2023Article
- Longitudinal Changes in Physical Function and Their Impact on Health Outcomes in COVID-19 Patients.Nutrients · 2023Article
- Upper extremity weakness: A novel risk factor for non-cardiovascular mortality among community-dwelling older adults.Archives of gerontology and geriatrics · 2023Article
- Self-perceived Weight and Mortality in Korean Adults Based on the Korea National Health and Nutrition Examination Survey Data Linked to Cause of Death Statistics.Journal of obesity & metabolic syndrome · 2022Article
- Handgrip strength weakness and asymmetry together are associated with cardiovascular outcomes in older outpatients: A prospective cohort study.Geriatrics & gerontology international · 2022Observational
- Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.Age and ageing · 2022Article
- Synergistic associations of visual and self-reported hearing acuity with low handgrip strength in older adults: a population-based cross-sectional study.BMC geriatrics · 2021Article
Corrections and comments
- Erratum issuedCorrection:2019
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether reduced handgrip strength, as a marker of muscle weakness, is linked with the risk of cardiovascular, cancer and all-cause mortality among older adults.
designWe used data from the 2006 to 2014 Korean longitudinal study of ageing study. Estimates of handgrip strength were collected using a handheld dynamometer. Cox proportional hazard models with time-varying covariates were used to estimate HRs and their 95% CIs for all-cause mortality. The cause-specific hazards regression analysis was also used to model cardiovascular and cancer mortality, by treating deaths from the cause of interest as events and other causes of death as censored.
participants5859 participants aged 50 years or older were followed up until death or until the date of censoring (31 December 2014). PRIMARY OUTCOME MEASURES: The study outcomes of interest were all-cause, cardiovascular and cancer mortality.
resultsOf the participants included in analyses, 515 individuals (8.8%) died, reflecting an overall crude mortality rate of 11.0 deaths per 1000 person-years. Participants in the lowest handgrip strength tertile showed an increased risk of all-cause and cardiovascular mortality evidenced by a multivariable adjusted HRs of 1.90 (95% CI 1.33 to 2.73) and 1.59 (95% Cl 1.08 to 2.34), respectively. However, there were no significant differences in the rates of cancer-related death, with HR of 1.29 (95% CI 0.92 to 1.81 [lowest vs highest tertile; p trend=0.21]).
conclusionThese results demonstrate that lower handgrip strength is an independent predictor of mortality among a population-based sample of Korean elderly; highlighting the importance of interventions targeted at enhancing muscle strength for improvements in survival at older ages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.