Evidence map›Paper›PMID 31072833›Full record

ArticleBlood advances2019

Height-corrected low bone density associates with severe outcomes in sickle cell disease: SCCRIP cohort study results.

Oyebimpe O Adesina, James G Gurney, Guolian Kang, Martha Villavicencio, Jason R Hodges, Wassim Chemaitilly, Sue C Kaste, Babette S Zemel, Jane S Hankins

Abstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Alendronate preserves bone mineral density in adults with sickle cell disease and osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  5. Should we use bisphosphonates to treat bone complications in sickle cell disease?Hematology. American Society of Hematology. Education Program · 2024
    Article
  6. A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  7. Clinical Vignettes, Part II: Eyes, Teeth, and Bone.Hematology/oncology clinics of North America · 2022
    Review
  8. Functional Outcomes for Children, Adolescents, and Young Adults with Osteonecrosis following Hip Core Decompression.Rehabilitation oncology (American Physical Therapy Association. Oncology Section) · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Bone morbidity in pediatric acute lymphoblastic leukemia.Annals of pediatric endocrinology & metabolism · 2020
    Article
  13. Osteonecrosis in sickle cell disease: an update on risk factors, diagnosis, and management.Hematology. American Society of Hematology. Education Program · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oyebimpe O AdesinaDivision of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA.ORCID 0000-0002-3082-9114
James G GurneySchool of Public Health, University of Memphis, Memphis, TN.
Guolian KangDepartment of Biostatistics.
Martha VillavicencioDepartment of Hematology.
Jason R HodgesDepartment of Hematology.ORCID 0000-0002-7418-6632
Wassim ChemaitillyDivision of Endocrinology, Department of Pediatric Medicine.
Sue C KasteDepartment of Diagnostic Imaging, and.
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA; and.ORCID 0000-0002-6164-7348
Jane S HankinsDepartment of Hematology.ORCID 0000-0003-4439-7321

Funding

PRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2M
Career Development in Clinical Hematology ResearchK12HL087165 · NHLBI · UNIVERSITY OF WASHINGTON · PI ABKOWITZ, JANIS L · 2006 to 2016
$4.0M
NHLBI NIH HHS K12 HL087165NHLBI NIH HHS R25 HL106365
6 · The paper itself

Abstract

Low bone mineral density (BMD) disproportionately affects people with sickle cell disease (SCD). Growth faltering is common in SCD, but most BMD studies in pediatric SCD cohorts fail to adjust for short stature. We examined low BMD prevalence in 6- to 18-year-olds enrolled in the Sickle Cell Clinical Research and Intervention Program (SCCRIP), an ongoing multicenter life span SCD cohort study initiated in 2014. We calculated areal BMD for chronological age and height-adjusted areal BMD (Ht-aBMD)

Indexed as

Absorptiometry, PhotonAdolescentAnemia, Sickle Cellbeta-ThalassemiaBody HeightBone DensityBone Diseases, MetabolicChildCohort StudiesFemaleGenotypeHumansLogistic ModelsLongitudinal StudiesMaleMultivariate Analysis

Identifiers

PMID31072833
PMCPMC6517655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.