Evidence map›Paper›PMID 31072760›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019

Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms.

Bader Chaarani, Kees-Jan Kan, Scott Mackey, Philip A Spechler, Alexandra Potter, Catherine Orr, Nicholas D'Alberto, Kelsey E Hudson, Tobias Banaschewski, Arun L W Bokde and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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  11. Consequences of adolescent drug use.Translational psychiatry · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Association of PolymorphismInternational journal of environmental research and public health · 2022
    Article
  17. Article
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  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Bader ChaaraniVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont. Electronic address: melmarsr@uvm.edu.
Kees-Jan KanVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Scott MackeyVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Philip A SpechlerVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Alexandra PotterVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Catherine OrrVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Nicholas D'AlbertoVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Kelsey E HudsonVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Anna CattrellMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
Patricia J ConrodDepartment of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec.
Sylvane DesrivièresMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Hamburg, Germany.
Penny GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging and Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Dimitri Papadopoulos-OrfanosNeurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
Tomáš PausRotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Austria.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Robert WhelanDepartment of Psychology, University College Dublin, Dublin, Ireland.
Stephen T HigginsVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Gunter SchumannDepartment of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec.
Robert R AlthoffVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Elliot A SteinThe National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland.
Hugh GaravanVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont. Electronic address: hgaravan@uvm.edu.
IMAGEN ConsortiumDepartment of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec.

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KLEMPERER, ELIAS M · 2013 to 2022
$21.3M
Functional and Structural Brain Circuits Underlying SmokingZIADA000573 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI STEIN, ELLIOT A · 2010 to 2021
$19.4M
Vermont Center on Tobacco Regulatory ScienceP50DA036114 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HIGGINS, STEPHEN T · 2013 to 2017
$19.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life CourseK08MH082116 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ALTHOFF, ROBERT RUSSELL · 2009 to 2013
$950k
Medical Research Council 93558NIBIB NIH HHS U54 EB020403NIDA NIH HHS P50 DA036114NIGMS NIH HHS P20 GM103644NIMH NIH HHS K08 MH082116Wellcome Trust
6 · The paper itself

Abstract

backgroundStudying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown.

methodsStructural and diffusion tensor magnetic resonance imaging data were acquired from a large sample of 14-year-old adolescents who completed an extensive battery of neuropsychological, clinical, personality, and drug-use assessments. Additional assessments were conducted at 16 years of age.

resultsExposure to smoking in adolescents, even at low doses, is linked to volume changes in the ventromedial prefrontal cortex and to altered neuronal connectivity in the corpus callosum. The longitudinal analyses strongly suggest that these effects are not preexisting conditions in those who progress to smoking. There was a genetic contribution wherein the volume reduction effects were magnified in smokers who were carriers of the high-risk genotype of the alpha 5 nicotinic receptor subunit gene, rs16969968.

conclusionsThese findings give insight into a mechanism involving genes, brain structure, and connectivity underlying why some adolescents find nicotine especially addictive.

Indexed as

AdolescentBrainCigarette SmokingDiffusion Tensor ImagingFemaleHumansMaleNerve Tissue ProteinsNeuropsychological TestsPolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite MatterCHRNA5 protein, humanNerve Tissue ProteinsReceptors, NicotinicAdolescentsfMRIGeneticsGray matter volumeLow smoking exposureNeuroimaging

Identifiers

PMID31072760
PMCPMC6709448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.