Evidence map›Paper›PMID 31072686›Full record

ArticleTrends in immunology2019

Monocytes Inadequately Fill In for Meningeal Macrophages.

Eric Song, Akiko Iwasaki

Open access · greenAbstract readComment
In one paragraph

Article in Trends in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Targeting macrophages in cancer immunotherapy.Signal transduction and targeted therapy · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eric SongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: akiko.iwasaki@yale.edu.
Howard Hughes Medical Institute · USYale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Meningeal lymphangiogenesis effect on malignancy ofglioblastoma.F30CA239444 · NCI · YALE UNIVERSITY · PI SONG, HOYEON ERIC · 2019 to 2021
$111k
Howard Hughes Medical InstituteNCI NIH HHS F30 CA239444NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

In the meninges, a unique subset of tissue-resident macrophages serves as a sentinel population against invading microorganisms while suppressing harmful inflammation. A recent report shows that when murine meningeal macrophages are killed by viruses, circulating monocytes repopulate the open niche. However, they fail to mimic all aspects of tissue-resident macrophages.

Indexed as

InfectionsMonocytesAnimalsInflammationMacrophagesMeningesMice

Identifiers

PMID31072686
PMCPMC8135183
OpenAlexW2944137986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.