Evidence map›Paper›PMID 31072339›Full record

ArticleBMC cancer2019

Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer.

A Hendricks, F Gieseler, S Nazzal, J H Bräsen, R Lucius, B Sipos, J H Claasen, Th Becker, S Hinz, G Burmeister and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

A HendricksDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, Hs. 18, 24105, Kiel, Germany. alexander.hendricks@uksh.de.ORCID http://orcid.org/0000-0002-7286-9245
F GieselerFirst Department of Medicine, UKSH, Campus Lübeck, Lübeck, Germany.
S NazzalDepartment of Medicine, Baruch Padeh Poria Medical Center, Faculty of Medicine in the Galilee, Bar-Ilan University, Tiberias, Lower Galilee, Israel.
J H BräsenInstitute of Pathology, Hannover Medical School, Hannover, Germany.
R LuciusInstitute of Anatomy, University of Kiel, Kiel, Germany.
B SiposInstitute of Pathology, University of Tübingen, Tübingen, Germany.
J H ClaasenClinic of Forensic Psychiatry Nette-Gut, Weißenthurm, Germany.
Th BeckerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, Hs. 18, 24105, Kiel, Germany.
S HinzDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, Hs. 18, 24105, Kiel, Germany.
G BurmeisterDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, Hs. 18, 24105, Kiel, Germany.
C SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, Hs. 18, 24105, Kiel, Germany.
C SchraderPraxis Dr. Schrader, Kiel, Germany.
University Hospital Schleswig-Holstein · DEBar-Ilan University · ILChristian-Albrechts-Universität zu Kiel · DEMedizinische Hochschule Hannover · DEOrthopädische Praxis · DEUniversitäres Kinderwunschzentrum Lübeck · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies. In terms of colorectal cancer, the impact of proliferation associated proteins is controversially debated. The aim of our study was to examine the expression of topoisomerase II α and minichromosome maintenance protein 6 and to correlate these findings with the clinical data.

methodsTissue samples of 619 patients in total were stained using the antibodies Ki-S4 and Ki-MCM6 targeting topoisomerase II α as well as minichromosome maintenance protein 6. The median rate of proliferation was correlated with clinical and follow up data.

resultsThe expression rate of minichromosome maintenance protein 6 is significantly higher than the proportion of topoisomerase II α in tumour cells (p < 0.001). A high expression of both proteins coincides with a beneficial outcome for the patient, indicating a favourable prognostic marker (p < 0.001 and p = 0.008).

conclusionsWe have demonstrated that high expression rates of proliferative markers is linked to a beneficial patient outcome. According to the general opinion, a high expression rate correlates with a poor patient outcome. In this study, we were able to refute this assertion.

Indexed as

AgedBiomarkers, TumorCell ProliferationColonColorectal NeoplasmsDisease-Free SurvivalDNA Topoisomerases, Type IIFemaleHumansMaleMiddle AgedMinichromosome Maintenance Complex Component 6Poly-ADP-Ribose Binding ProteinsPrognosisRectumRetrospective StudiesBiomarkers, TumorDNA Topoisomerases, Type IIMCM6 protein, humanMinichromosome Maintenance Complex Component 6Poly-ADP-Ribose Binding ProteinsTOP2A protein, humanColorectal cancerMinichromosome maintenance protein 6Prognostic markerProliferative proteinsTopoisomerase II α

Identifiers

PMID31072339
PMCPMC6507179
OpenAlexW2947447065

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.