Evidence map›Paper›PMID 31072301›Full record

ArticleBMC genomics2019

Comparative transcriptome analysis of trout skin pigment cells.

Ida Djurdjevič, Tomasz Furmanek, Seita Miyazawa, Simona Sušnik Bajec

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  9. Studies of Turing pattern formation in zebrafish skin.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021
    Review
  10. Malpigmentation of Common Sole (Animals : an open access journal from MDPI · 2021
    Article
  11. Dark-rearing uncovers novel gene expression patterns in an obligate cave-dwelling fish.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020
    Article
  12. Topological data analysis of zebrafish patterns.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Ida DjurdjevičDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230, Domžale, Slovenia.
Tomasz FurmanekInstitute of Marine Research, Bergen, Norway.
Seita MiyazawaGraduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Simona Sušnik BajecDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230, Domžale, Slovenia. simona.susnik@bf.uni-lj.si.ORCID http://orcid.org/0000-0003-1283-2720
University of Ljubljana · SINorwegian Institute of Marine Research · NOUbe Frontier University · JP

Funding

Javna Agencija za Raziskovalno Dejavnost RS P4-0220Javna Agencija za Raziskovalno Dejavnost RS Postgraduate research funding
6 · The paper itself

Abstract

backgroundEnormous variability in skin colour and patterning is a characteristic of teleost fish, including Salmonidae fishes, which present themselves as a suitable model for studying mechanisms of pigment patterning. In order to screen for candidate genes potentially involved in the specific skin pigment pattern in marble trout (labyrinthine skin pattern) and brown trout (spotted skin pattern), we conducted comparative transcriptome analysis between differently pigmented dermis sections of the adult skin of the two species.

resultsDifferentially expressed genes (DEGs) possibly associated with skin pigment pattern were identified. The expression profile of 27 DEGs was further tested with quantitative real-time PCR on a larger number of samples. Expression of a subset of ten of these genes was analysed in hybrid (marble x brown) trout individuals and compared with the complexity of their skin pigment pattern. A correlation between the phenotype and the expression profile assessed for hybrid individuals was detected for four (gja5, clcn2, cdkn1a and tjp1) of the ten candidate genes tested. The potential role of these genes in skin pigment pattern maintenance is discussed.

conclusionsOur results indicate that the maintenance of different pigment patterns in trout is dependent upon specific communication-involving gap junctions, tight junctions and ion channels-between chromatophores present in differentially pigmented skin regions.

Indexed as

Skin PigmentationAnimalsFish ProteinsGene Expression ProfilingSkinTranscriptomeTroutFish ProteinsDEGPigment cellqPCRRNA-seqSalmo marmoratusSalmo trutta

Identifiers

PMID31072301
PMCPMC6509846
OpenAlexW2946970541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.