Evidence map›Paper›PMID 31072143›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2019

A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees.

Songtao Wu, Yanfang Yang, Bo Liu, Zhoutao Xie, Weichen Xiong, Pengfei Hao, Wenping Xiao, Yuan Sun, Zhongzhu Ai, Hezhen Wu

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Songtao Wua Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Yanfang Yanga Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Bo Liua Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Zhoutao Xiea Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Weichen Xionga Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Pengfei Haoa Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Wenping Xiaoa Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Yuan Suna Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Zhongzhu Aia Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Hezhen Wua Faculty of Pharmacy , Hubei University of Chinese Medicine , Wuhan , China.
Hubei University of Chinese Medicine · CNShanghai Innovative Research Center of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explored the possible bioactive ingredients and target protein of Rostellularia procumbens (L.) Nees. The results of optical turbidimetry revealed that the ethyl acetate extraction obtained from R. procumbens (L.) Nees could inhibit platelet aggregation. Gene chip was used to investigate differentially expressed genes. According to the results of the gene chip, the targets of compounds isolated from the ethyl acetate extraction were predicted by network pharmacology. Computational studies revealed that chinensinaphthol methyl ether and neojusticin B may target the integrin α

Indexed as

AcanthaceaeBenzene DerivativesDioxolanesDose-Response Relationship, DrugEthersHumansLignansPlatelet AggregationPlatelet Aggregation InhibitorsPlatelet Function TestsStructure-Activity RelationshipBenzene Derivativeschinensinaphthol methyl etherDioxolanesEthersjusticidinsLignansPlatelet Aggregation InhibitorsChinensinaphthol methyl ethergene chipintegrin αmicroscale thermophoresisneojusticin Bnetwork pharmacologyplatelet aggregationPrometheus NT.48

Identifiers

PMID31072143
PMCPMC6522982
OpenAlexW2944194081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.