Evidence map›Paper›PMID 31072136›Full record

ArticleCartilage2021

Osteochondral Repair and Electromechanical Evaluation of Custom 3D Scaffold Microstructured by Direct Laser Writing Lithography.

Justinas Maciulaitis, Milda Miskiniene, Sima Rekštytė, Maksim Bratchikov, Adas Darinskas, Agne Simbelyte, Gintaras Daunoras, Aida Laurinaviciene, Arvydas Laurinavicius, Rimtautas Gudas and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Justinas MaciulaitisInstitute of Sports, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0002-1265-8657
Milda MiskinieneLaboratory of Immunology, National Institute of Cancer, Vilnius, Lithuania.
Sima RekštytėLaser Research Center, Faculty of Physics, Vilnius University, Vilnius, Lithuania.
Maksim BratchikovDepartment of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Adas DarinskasLaboratory of Immunology, National Institute of Cancer, Vilnius, Lithuania.
Agne SimbelyteNational Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Gintaras DaunorasNon-infectious Disease Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Aida LaurinavicieneNational Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Arvydas LaurinaviciusNational Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Rimtautas GudasInstitute of Sports, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Mangirdas MalinauskasLaser Research Center, Faculty of Physics, Vilnius University, Vilnius, Lithuania.
Romaldas MaciulaitisInstitute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vilnius University · LTLithuanian University of Health Sciences · LTNational Cancer Institute · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to assess a novel 3D microstructured scaffold seeded with allogeneic chondrocytes (cells) in a rabbit osteochondral defect model.

designDirect laser writing lithography in pre-polymers was employed to fabricate custom silicon-zirconium containing hybrid organic-inorganic (HOI) polymer SZ2080 scaffolds of a predefined morphology. Hexagon-pored HOI scaffolds were seeded with chondrocytes (cells), and tissue-engineered cartilage biocompatibility, potency, efficacy, and shelf-life

resultsType II collagen gene upregulation and protein secretion was maintained up to 8 days in seeded HOI.

conclusionsHOI material is biocompatible for up to 8 days

Indexed as

ChondrocytesTissue ScaffoldsAnimalsLasersRabbitsTissue EngineeringWritingautologous chondrocytebiomechanicscellschondrocyteselectromechanicsgraftsin vivorepairtissue engineering

Identifiers

PMID31072136
PMCPMC8804810
OpenAlexW2944310956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.