Evidence map›Paper›PMID 31072044›Full record

ArticleBiomolecules2019

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of

Marios G Krokidis, Zara Molphy, Eleni K Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Accessing New Phenanthroline-Oxazine Scaffolds as Copper-Dependent DNA Damaging Probes.Chembiochem : a European journal of chemical biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Marios G KrokidisInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. m.krokidis@inn.demokritos.gr.
Zara MolphySchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, 9 Dublin, Ireland. zara.molphy2@mail.dcu.ie.
Eleni K EfthimiadouInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. efthim@chem.uoa.gr.
Marianna KokoliInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. marianna_kokoli@yahoo.gr.
Smaragda-Maria ArgyriInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. argyri@student.chalmers.se.
Irini DousiInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. i.dousi@inn.demokritos.gr.
Annalisa MasiISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy. annalisa.masi@isof.cnr.it.
Kyriakos PapadopoulosInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. k.papadopoulos@inn.demokritos.gr.
Andrew KellettSchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, 9 Dublin, Ireland. andrew.kellett@dcu.ie.
Chryssostomos ChatgilialogluInstitute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi-Athens, Greece. chrys@isof.cnr.it.
National Centre of Scientific Research "Demokritos" · GRDublin City University · IENational and Kapodistrian University of Athens · GRInstitute of Organic Synthesis and Photoreactivity · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties. A series of

Indexed as

AcridinesAcridonesBenzothiazolesBiphenyl CompoundsBreast NeoplasmsCell SurvivalDNADNA Topoisomerases, Type IFemaleFree Radical ScavengersHumansMCF-7 CellsPicratesSulfonic AcidsWound Healing1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAcridinesAcridonesBenzothiazolesBiphenyl CompoundsDNADNA Topoisomerases, Type IFree Radical ScavengersPicratesSulfonic Acidscytotoxic activityDNA bindingDNA intercalationN,N′-dialkyl-9,9′-biacridylidenesradical scavenging capacitytopoisomerase I

Identifiers

PMID31072044
PMCPMC6572364
OpenAlexW2944359022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.