Evidence map›Paper›PMID 31071971›Full record

ArticleJournal of clinical medicine2019

Longitudinal Changes in Insulin Resistance in Normal Weight, Overweight and Obese Individuals.

Alice Tang, Adelle C F Coster, Katherine T Tonks, Leonie K Heilbronn, Nicholas Pocock, Louise Purtell, Matthew Govendir, Jackson Blythe, Jialiang Zhang, Aimin Xu and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02017210 (Insulin-sensitive Obesity), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02017210 completednot on this map

Insulin-sensitive Obesity: Prospective and Interventional Studies

TypeobservationalSponsorGarvan Institute of Medical ResearchRan2013 to 2016Enrolled57ConditionsInsulin Sensitivity/Resistance, Obesity
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Alice TangDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. a.tang@unswalumni.com.
Adelle C F CosterSchool of Mathematics and Statistics, UNSW Sydney, Sydney 2052, Australia. A.Coster@unsw.edu.au.ORCID 0000-0002-5572-6832
Katherine T TonksDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. k.tonks@garvan.org.au.
Leonie K HeilbronnAdelaide Medical School, University of Adelaide, Adelaide 5005, Australia. leonie.heilbronn@adelaide.edu.au.
Nicholas PocockSt. Vincent's Clinical School, UNSW Sydney, Sydney 2010, Australia. n.pocock@unsw.edu.au.
Louise PurtellDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. louise.purtell@qut.edu.au.
Matthew GovendirDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. m.govendir@unsw.edu.au.
Jackson BlytheDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. jackson.blythe@outlook.com.ORCID 0000-0001-8889-2709
Jialiang ZhangState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China. hjzhang@hku.hk.
Aimin XuState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China. amxu@hku.hk.
Donald J ChisholmDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. d.chisholm@garvan.org.au.
Nathan A JohnsonFaculty of Health Sciences, The University of Sydney, Camperdown 2006, Australia. nathan.johnson@sydney.edu.au.
Jerry R GreenfieldDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. j.greenfield@garvan.org.au.
Dorit Samocha-BonetDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney 2010, Australia. d.samochabonet@garvan.org.au.ORCID 0000-0001-9422-7852
Garvan Institute of Medical Research · AUUniversity of Hong Kong · HKUNSW Sydney · AUThe University of Adelaide · AUThe University of Sydney · AU

Funding

Diabetes Australia Research Trust N/A
6 · The paper itself

Abstract

backgroundLarge cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing in older age. We aimed to assess the fate of insulin sensitivity per se over time in overweight and obese individuals.

methodsIndividuals studied using the hyperinsulinaemic-euglycaemic clamp at the Garvan Institute of Medical Research from 2008 to 2010 (

resultsIn the whole cohort, M/I did not change over time (

conclusionsThe similarity in insulin sensitivity between the Ob

Indexed as

fat-free masshyperinsulinaemic-euglycaemic clampinsulin resistanceliver fatobesity

Identifiers

PMID31071971
PMCPMC6572215
OpenAlexW2944409784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.