Evidence map›Paper›PMID 31071921›Full record

ArticleInternational journal of molecular sciences2019

CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy.

Thomas J LaRocca, Perry Altman, Andrew A Jarrah, Ron Gordon, Edward Wang, Lahouaria Hadri, Mark W Burke, Georges E Haddad, Roger J Hajjar, Sima T Tarzami

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  15. Inflammation and Cardiovascular Diseases: The Most Recent Findings.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Thomas J LaRoccaCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. thomas.laRocca@mssm.edu.
Perry AltmanCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. perry.altman@mssm.edu.
Andrew A JarrahDepartment of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA. andrewjarrah@gmail.com.
Ron GordonCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. rongordon@mssm.edu.
Edward WangCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. edward.wamg@mssm.edu.
Lahouaria HadriCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. Lahouaria.hadri@mssm.edu.
Mark W BurkeDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20060, USA. mark.burke@howard.edu.
Georges E HaddadDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20060, USA. ghaddad@howard.edu.
Roger J HajjarCardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10128, USA. rogerhajjar@mssm.edu.
Sima T TarzamiDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20060, USA. sima.tarzami@howard.edu.
Icahn School of Medicine at Mount Sinai · USHoward University · USTufts University · US

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI William M. Southerland · 2019 to 2026
$37.7M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
Anti-Remodeling Effects of the CXCL12/CXCR4 Axis in the Cardiac MyocyteF30HL096344 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LAROCCA, THOMAS · 2009 to 2011
$71k
American Heart Association 10GRNT4180006NHLBI NIH HHS 1F30HL096344-01NHLBI NIH HHS F30 HL096344NIMHD NIH HHS G12 MD007597NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

Activation of multiple pathways is associated with cardiac hypertrophy and heart failure. We previously published that CXCR4 negatively regulates β-adrenergic receptor (β-AR) signaling and ultimately limits β-adrenergic diastolic (Ca

Indexed as

AnimalsAtrial Natriuretic FactorCardiomyopathiesChemokine CXCL12Disease Models, AnimalGene Expression RegulationHeartHeart FailureHumansIsoproterenolMiceMice, KnockoutMitochondria, HeartMyocytes, CardiacReceptors, Adrenergic, betaReceptors, CXCR4Atrial Natriuretic FactorChemokine CXCL12CXCR4 protein, humanCXCR4 protein, mouseIsoproterenolReceptors, Adrenergic, betaReceptors, CXCR4cardiomyopathychemokine receptor-4 (CXCR4)CXCL12mitochondria

Identifiers

PMID31071921
PMCPMC6539363
OpenAlexW2943921432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.